Open Access
Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer
Kanamat Efendiev
1, 2, 3
,
Polina Alekseeva
2
,
Kirill Linkov
2
,
Artem Olegovich Shiryaev
4
,
Tatiana Pisareva
4
,
Aida Gilyadova
4
,
Igor V. Reshetov
4
,
I. V. Reshetov
4
,
Arina Voitova
5
,
A.V. Voitova
5
,
Victor Loschenov
1, 2, 3
5
BIOSPEC Ltd., Moscow, Russia
|
Publication type: Journal Article
Publication date: 2024-02-01
scimago Q2
wos Q3
SJR: 0.724
CiteScore: 5.8
Impact factor: 2.6
ISSN: 15721000, 18731597
PubMed ID:
38211779
Oncology
Biophysics
Pharmacology (medical)
Dermatology
Abstract
The study is aimed at developing a method for monitoring photodynamic therapy (PDT) of a tumor using chlorin-type photosensitizers (PSs). Lack of monitoring of chlorin e6 (Cе6) photobleaching, hemoglobin oxygenation and blood flow during light exposure can limit the PDT effectiveness. Phototheranostics includes spectral-fluorescence diagnostics of Ce6 distribution in the NIR range and PDT with simultaneous assessment of hemoglobin oxygenation and tumor blood flow. Fluorescence diagnostics and PDT were performed using the single laser λexc=660±5 nm. Combined spectroscopic PDT monitoring method allowed simultaneous estimation of Ce6 photobleaching, hemoglobin oxygenation and tumor vascular thrombosis during PDT without interrupting the therapeutic light exposure. The developed method of tumor phototheranostics using chlorin-type PSs makes it possible to personalize the duration of therapeutic light exposure during PDT.
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Metrics
8
Total citations:
8
Citations from 2025:
4
(50%)
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RIS |
BibTex
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GOST
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Efendiev K. et al. Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer // Photodiagnosis and Photodynamic Therapy. 2024. Vol. 45. p. 103969.
GOST all authors (up to 50)
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Efendiev K., Alekseeva P., Alekseeva P. M., Linkov K., Shiryaev A. O., Pisareva T., Gilyadova A., Reshetov I. V., Reshetov I. V., Voitova A., Voitova A., Loschenov V. Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer // Photodiagnosis and Photodynamic Therapy. 2024. Vol. 45. p. 103969.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.pdpdt.2024.103969
UR - https://linkinghub.elsevier.com/retrieve/pii/S1572100024000085
TI - Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer
T2 - Photodiagnosis and Photodynamic Therapy
AU - Efendiev, Kanamat
AU - Alekseeva, Polina
AU - Alekseeva, Polina M
AU - Linkov, Kirill
AU - Shiryaev, Artem Olegovich
AU - Pisareva, Tatiana
AU - Gilyadova, Aida
AU - Reshetov, Igor V.
AU - Reshetov, I. V.
AU - Voitova, Arina
AU - Voitova, A.V.
AU - Loschenov, Victor
PY - 2024
DA - 2024/02/01
PB - Elsevier
SP - 103969
VL - 45
PMID - 38211779
SN - 1572-1000
SN - 1873-1597
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2024_Efendiev,
author = {Kanamat Efendiev and Polina Alekseeva and Polina M Alekseeva and Kirill Linkov and Artem Olegovich Shiryaev and Tatiana Pisareva and Aida Gilyadova and Igor V. Reshetov and I. V. Reshetov and Arina Voitova and A.V. Voitova and Victor Loschenov},
title = {Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer},
journal = {Photodiagnosis and Photodynamic Therapy},
year = {2024},
volume = {45},
publisher = {Elsevier},
month = {feb},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1572100024000085},
pages = {103969},
doi = {10.1016/j.pdpdt.2024.103969}
}