Elsevier
Pediatric Neurology
,  volume 165 ,  pages 74-77

Barriers to Recruitment in an Acute Neonatal Seizure Drug Trial: Lessons from a Randomized, Double-Blind, Controlled Study of Intravenous Phenobarbital

Shani Israel 1
, 
Courtney Lowe 1
, 
Zahr Alkhadem 1
, 
Emmeline Roth 2
, 
Lindsay Ruffini 1
, 
Tammy Tsuchida 1, 3
, 
Tayyba Anwar 1, 3
1
 
2
 
Janssen Research and Development, Raritan, New Jersey | 
3
 
Publication type: Journal Article
Publication date: 2025-04-01
Elsevier
scimago Q1
wos Q2
SJR: 0.825
CiteScore: 3.9
Impact factor: 2.1
ISSN: 08878994, 18735150
Abstract
BackgroundDespite the prevalence of seizures among neonates, neonatal seizure drug trials are rarely conducted due to ethical considerations, difficulties in trial design, and limited hospital resources and personnel. The purpose of this prospective consecutive case series is to highlight the experiences and challenges encountered by a single study site in participant recruitment for an acute neonatal seizure treatment trial that was active between January 24, 2022, and February 1, 2023.
Found 

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
0
Share
Cite this
GOST |
Cite this
GOST Copy
Israel S. et al. Barriers to Recruitment in an Acute Neonatal Seizure Drug Trial: Lessons from a Randomized, Double-Blind, Controlled Study of Intravenous Phenobarbital // Pediatric Neurology. 2025. Vol. 165. pp. 74-77.
GOST all authors (up to 50) Copy
Israel S., Lowe C., Alkhadem Z., Roth E., Ruffini L., Tsuchida T., Anwar T. Barriers to Recruitment in an Acute Neonatal Seizure Drug Trial: Lessons from a Randomized, Double-Blind, Controlled Study of Intravenous Phenobarbital // Pediatric Neurology. 2025. Vol. 165. pp. 74-77.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.pediatrneurol.2025.01.020
UR - https://linkinghub.elsevier.com/retrieve/pii/S0887899425000281
TI - Barriers to Recruitment in an Acute Neonatal Seizure Drug Trial: Lessons from a Randomized, Double-Blind, Controlled Study of Intravenous Phenobarbital
T2 - Pediatric Neurology
AU - Israel, Shani
AU - Lowe, Courtney
AU - Alkhadem, Zahr
AU - Roth, Emmeline
AU - Ruffini, Lindsay
AU - Tsuchida, Tammy
AU - Anwar, Tayyba
PY - 2025
DA - 2025/04/01
PB - Elsevier
SP - 74-77
VL - 165
SN - 0887-8994
SN - 1873-5150
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Israel,
author = {Shani Israel and Courtney Lowe and Zahr Alkhadem and Emmeline Roth and Lindsay Ruffini and Tammy Tsuchida and Tayyba Anwar},
title = {Barriers to Recruitment in an Acute Neonatal Seizure Drug Trial: Lessons from a Randomized, Double-Blind, Controlled Study of Intravenous Phenobarbital},
journal = {Pediatric Neurology},
year = {2025},
volume = {165},
publisher = {Elsevier},
month = {apr},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0887899425000281},
pages = {74--77},
doi = {10.1016/j.pediatrneurol.2025.01.020}
}