Elsevier
Pediatric Neurology
,  volume 166 ,  pages 55-64

Seizures may worsen outcomes of neonatal hypoxic ischemic encephalopathy: a longitudinal serum biomarkers study

Khyzer B Aziz 1, 2, 3
, 
Jordan R. Kuiper 4
, 
Alison Kilborn 1
, 
Hrishikesh Kambli 1
, 
Srishti Jayakumar 1, 2
, 
Gwendolyn J Gerner 2, 5
, 
Aylin Tekes 2, 6
, 
Charlamaine Parkinson 1, 2
, 
Ernest M. Graham 2, 7
, 
Carl E. Stafstrom 2, 5
, 
Christopher Campbell 8
, 
Catherine Demos 8
, 
Martin Stengelin 8
, 
George Sigal 8
, 
Jacob Wohlstadter 8
, 
Allen D. Everett 9
, 
Frances J. Northington 1, 2
, 
Raul Chavez-Valdez 1, 2
1
 
2
 
3
 
4
 
5
 
6
 
7
 
8
 
Meso Scale Diagnostics, LLC., Rockville, Maryland | 
9
 
Publication type: Journal Article
Publication date: 2025-05-01
Elsevier
scimago Q1
wos Q2
SJR: 0.825
CiteScore: 3.9
Impact factor: 2.1
ISSN: 08878994, 18735150
Abstract
BackgroundUnderstanding if neonatal seizures (Sz) worsen brain injury and outcomes would optimize treatment decisions. We hypothesized that serum central nervous system–specific biomarkers would discriminate neonates with Sz and relate to outcomes.
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GOST |
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GOST Copy
Aziz K. B. et al. Seizures may worsen outcomes of neonatal hypoxic ischemic encephalopathy: a longitudinal serum biomarkers study // Pediatric Neurology. 2025. Vol. 166. pp. 55-64.
GOST all authors (up to 50) Copy
Aziz K. B., Kuiper J. R., Kilborn A., Kambli H., Jayakumar S., Gerner G. J., Tekes A., Parkinson C., Graham E. M., Stafstrom C. E., Campbell C., Demos C., Stengelin M., Sigal G., Wohlstadter J., Everett A. D., Northington F. J., Chavez-Valdez R. Seizures may worsen outcomes of neonatal hypoxic ischemic encephalopathy: a longitudinal serum biomarkers study // Pediatric Neurology. 2025. Vol. 166. pp. 55-64.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.pediatrneurol.2025.02.008
UR - https://linkinghub.elsevier.com/retrieve/pii/S0887899425000499
TI - Seizures may worsen outcomes of neonatal hypoxic ischemic encephalopathy: a longitudinal serum biomarkers study
T2 - Pediatric Neurology
AU - Aziz, Khyzer B
AU - Kuiper, Jordan R.
AU - Kilborn, Alison
AU - Kambli, Hrishikesh
AU - Jayakumar, Srishti
AU - Gerner, Gwendolyn J
AU - Tekes, Aylin
AU - Parkinson, Charlamaine
AU - Graham, Ernest M.
AU - Stafstrom, Carl E.
AU - Campbell, Christopher
AU - Demos, Catherine
AU - Stengelin, Martin
AU - Sigal, George
AU - Wohlstadter, Jacob
AU - Everett, Allen D.
AU - Northington, Frances J.
AU - Chavez-Valdez, Raul
PY - 2025
DA - 2025/05/01
PB - Elsevier
SP - 55-64
VL - 166
SN - 0887-8994
SN - 1873-5150
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Aziz,
author = {Khyzer B Aziz and Jordan R. Kuiper and Alison Kilborn and Hrishikesh Kambli and Srishti Jayakumar and Gwendolyn J Gerner and Aylin Tekes and Charlamaine Parkinson and Ernest M. Graham and Carl E. Stafstrom and Christopher Campbell and Catherine Demos and Martin Stengelin and George Sigal and Jacob Wohlstadter and Allen D. Everett and Frances J. Northington and Raul Chavez-Valdez},
title = {Seizures may worsen outcomes of neonatal hypoxic ischemic encephalopathy: a longitudinal serum biomarkers study},
journal = {Pediatric Neurology},
year = {2025},
volume = {166},
publisher = {Elsevier},
month = {may},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0887899425000499},
pages = {55--64},
doi = {10.1016/j.pediatrneurol.2025.02.008}
}