Elsevier
Pharmacology and Therapeutics
,  volume 252 ,  pages 108560

What matters in aging is signaling for responsiveness

Sang Chul Park 1
, 
Young Sam Lee 2, 3
, 
Kyung A Cho 4
, 
Sung Young Kim 5
, 
Yun-Il Lee 3
, 
Seung-Rock LEE 4
, 
In Kyoung Lim 6
1
 
2
 
3
 
4
 
5
 
6
 
Publication type: Journal Article
Publication date: 2023-12-01
Elsevier
scimago Q1
wos Q1
SJR: 3.800
CiteScore: 26.2
Impact factor: 12.5
ISSN: 01637258, 1879016X
Pharmacology
Pharmacology (medical)
Abstract
Biological responsiveness refers to the capacity of living organisms to adapt to changes in both their internal and external environments through physiological and behavioral mechanisms. One of the prominent aspects of aging is the decline in this responsiveness, which can lead to a deterioration in the processes required for maintenance, survival, and growth. The vital link between physiological responsiveness and the essential life processes lies within the signaling systems. To devise effective strategies for controlling the aging process, a comprehensive reevaluation of this connecting loop is imperative. This review aims to explore the impact of aging on signaling systems responsible for responsiveness and introduce a novel perspective on intervening in the aging process by restoring the compromised responsiveness. These innovative mechanistic approaches for modulating altered responsiveness hold the potential to illuminate the development of action plans aimed at controlling the aging process and treating age-related disorders.
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GOST Copy
Park S. C. et al. What matters in aging is signaling for responsiveness // Pharmacology and Therapeutics. 2023. Vol. 252. p. 108560.
GOST all authors (up to 50) Copy
Park S. C., Lee Y. S., Cho K. A., Kim S. Y., Lee Y., LEE S., Lim I. K. What matters in aging is signaling for responsiveness // Pharmacology and Therapeutics. 2023. Vol. 252. p. 108560.
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RIS Copy
TY - JOUR
DO - 10.1016/j.pharmthera.2023.108560
UR - https://doi.org/10.1016/j.pharmthera.2023.108560
TI - What matters in aging is signaling for responsiveness
T2 - Pharmacology and Therapeutics
AU - Park, Sang Chul
AU - Lee, Young Sam
AU - Cho, Kyung A
AU - Kim, Sung Young
AU - Lee, Yun-Il
AU - LEE, Seung-Rock
AU - Lim, In Kyoung
PY - 2023
DA - 2023/12/01
PB - Elsevier
SP - 108560
VL - 252
PMID - 37952903
SN - 0163-7258
SN - 1879-016X
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Park,
author = {Sang Chul Park and Young Sam Lee and Kyung A Cho and Sung Young Kim and Yun-Il Lee and Seung-Rock LEE and In Kyoung Lim},
title = {What matters in aging is signaling for responsiveness},
journal = {Pharmacology and Therapeutics},
year = {2023},
volume = {252},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.pharmthera.2023.108560},
pages = {108560},
doi = {10.1016/j.pharmthera.2023.108560}
}