Guggulsterone Suppresses Osteosarcoma Progression by Inhibiting Glycolysis through MAPK Signaling Pathway
Qijing Wang
1, 2
,
Xuhui Yuan
1, 3, 4
,
Hongyan Li
1, 3, 4
,
Jiayu Li
1, 3, 4
,
Zhaoyang Wu
1, 3, 4
,
ZHANG WENMING
1, 3, 4
,
Xinyu Fang
1, 3, 4
Publication type: Journal Article
Publication date: 2025-08-01
scimago Q1
wos Q1
SJR: 1.694
CiteScore: 11.6
Impact factor: 8.3
ISSN: 09447113, 1618095X
Abstract
BackgroundOsteosarcoma (OS) represents an aggressive primary cancer originating in bone. It is predominantly diagnosed in pediatric and young adult populations, constituting approximately 20 % of bone malignancies in these age groups. Treatment efficacy is often hampered by chemoresistance. Guggulsterone (GS), a plant-derived sterol from Commiphora wightii, demonstrates promising anti-tumor potential, yet its effects on OS remain unexplored.
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Wang Q. et al. Guggulsterone Suppresses Osteosarcoma Progression by Inhibiting Glycolysis through MAPK Signaling Pathway // Phytomedicine. 2025. Vol. 144. p. 156949.
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Wang Q., Yuan X., Li H., Li J., Wu Z., WENMING Z., Fang X. Guggulsterone Suppresses Osteosarcoma Progression by Inhibiting Glycolysis through MAPK Signaling Pathway // Phytomedicine. 2025. Vol. 144. p. 156949.
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TY - JOUR
DO - 10.1016/j.phymed.2025.156949
UR - https://linkinghub.elsevier.com/retrieve/pii/S0944711325005872
TI - Guggulsterone Suppresses Osteosarcoma Progression by Inhibiting Glycolysis through MAPK Signaling Pathway
T2 - Phytomedicine
AU - Wang, Qijing
AU - Yuan, Xuhui
AU - Li, Hongyan
AU - Li, Jiayu
AU - Wu, Zhaoyang
AU - WENMING, ZHANG
AU - Fang, Xinyu
PY - 2025
DA - 2025/08/01
PB - Elsevier
SP - 156949
VL - 144
SN - 0944-7113
SN - 1618-095X
ER -
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@article{2025_Wang,
author = {Qijing Wang and Xuhui Yuan and Hongyan Li and Jiayu Li and Zhaoyang Wu and ZHANG WENMING and Xinyu Fang},
title = {Guggulsterone Suppresses Osteosarcoma Progression by Inhibiting Glycolysis through MAPK Signaling Pathway},
journal = {Phytomedicine},
year = {2025},
volume = {144},
publisher = {Elsevier},
month = {aug},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0944711325005872},
pages = {156949},
doi = {10.1016/j.phymed.2025.156949}
}