Elsevier
Phytochemistry
,  том 232 ,  страницы 114373

Piperidine and bis-piperidine alkaloids from the peels of Areca catechu and their monoamine oxidases inhibitory activity

Тип публикации: Journal Article
Дата публикации: 2025-04-01
Elsevier
SCImago Q1
Tоп 10% SCImago
WOS Q2
БС1
SJR: 0.645
CiteScore: 7.1
Impact factor: 3.4
ISSN: 00319422, 18733700
Краткое описание
Eleven undescribed piperidine alkaloids, arecachines A‒J (1–11), were isolated from the peels of Areca catechu. Compounds 8–11 are featured as bis-piperidine alkaloids. Their structures were elucidated by analysis of UV, IR, HRESIMS, 1D and 2D NMR spectra. Compounds 1–4, 6, and 8–11 were evaluated for the monoamine oxidases (MAOs) inhibitory activity. Among them, compounds 3, 4, 6, and 10 showed MAOA inhibitory activity with IC50 values of 7.85–55.96 μM, while compounds 1–4, 8, 10, and 11 showed MAOB inhibitory activity with IC50 values of 11.92–77.87 μM.
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Wang S. et al. Piperidine and bis-piperidine alkaloids from the peels of Areca catechu and their monoamine oxidases inhibitory activity // Phytochemistry. 2025. Vol. 232. p. 114373.
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Wang S., WANG D., Zhang X., Li Z., Lu D., Jiang Z., Ma M., Song M., Xiaoqi Zhang X. Z. Piperidine and bis-piperidine alkaloids from the peels of Areca catechu and their monoamine oxidases inhibitory activity // Phytochemistry. 2025. Vol. 232. p. 114373.
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TY - JOUR
DO - 10.1016/j.phytochem.2024.114373
UR - https://linkinghub.elsevier.com/retrieve/pii/S0031942224004102
TI - Piperidine and bis-piperidine alkaloids from the peels of Areca catechu and their monoamine oxidases inhibitory activity
T2 - Phytochemistry
AU - Wang, Song
AU - WANG, De-zhi
AU - Zhang, Xia
AU - Li, Zi-Wei
AU - Lu, Dong-Hao
AU - Jiang, Zheng-Jin
AU - Ma, Min
AU - Song, Min
AU - Xiaoqi Zhang, Xiaoqi Zhang
PY - 2025
DA - 2025/04/01
PB - Elsevier
SP - 114373
VL - 232
PMID - 39708993
SN - 0031-9422
SN - 1873-3700
ER -
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@article{2025_Wang,
author = {Song Wang and De-zhi WANG and Xia Zhang and Zi-Wei Li and Dong-Hao Lu and Zheng-Jin Jiang and Min Ma and Min Song and Xiaoqi Zhang Xiaoqi Zhang},
title = {Piperidine and bis-piperidine alkaloids from the peels of Areca catechu and their monoamine oxidases inhibitory activity},
journal = {Phytochemistry},
year = {2025},
volume = {232},
publisher = {Elsevier},
month = {apr},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0031942224004102},
pages = {114373},
doi = {10.1016/j.phytochem.2024.114373}
}
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