Phytochemistry Letters, volume 59, pages 20-23
Synthesis and antifungal activity of 2,4-dihydroxy-5-methylphenyl ethanone derivatives against phytopathogenic fungi in vitro
Publication type: Journal Article
Publication date: 2024-02-01
Journal:
Phytochemistry Letters
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 1.7
ISSN: 18743900, 18767486
Biochemistry
Plant Science
Biotechnology
Agronomy and Crop Science
Abstract
In an endeavor to pinpoint the structural constituents vital for the biological activity of 2,4-dihydroxy-5-methylphenyl ethanone, a series of its ether derivatives was synthesized and examined for their antifungal activities against five notable phytopathogenic fungi. The bioassay revealed that compounds 2, 3a, 3g, 3j and 3k manifested a broad spectrum of antifungal efficacy. Notably, compound 3g was identified as especially potent, with IC50 values ranging from 16.52 to 37.52 μg/mL, outperforming the standard thiabendazole. The data underscore compound 3g as a prospective candidate for the development of an innovative antifungal agent. A comprehensive structure-activity relationship (SAR) study of the acetophenones was also conducted.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Lin J. et al. Synthesis and antifungal activity of 2,4-dihydroxy-5-methylphenyl ethanone derivatives against phytopathogenic fungi in vitro // Phytochemistry Letters. 2024. Vol. 59. pp. 20-23.
GOST all authors (up to 50)
Copy
Lin J., Zhang C., Zhu Y., Zhao C., Han Z., Hu D., Shi W. Synthesis and antifungal activity of 2,4-dihydroxy-5-methylphenyl ethanone derivatives against phytopathogenic fungi in vitro // Phytochemistry Letters. 2024. Vol. 59. pp. 20-23.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.phytol.2023.11.008
UR - https://doi.org/10.1016/j.phytol.2023.11.008
TI - Synthesis and antifungal activity of 2,4-dihydroxy-5-methylphenyl ethanone derivatives against phytopathogenic fungi in vitro
T2 - Phytochemistry Letters
AU - Lin, Jia-Sheng
AU - Zhang, Cuiping
AU - Zhu, Yuchun
AU - Zhao, Chunyan
AU - Han, Zeng-Hui
AU - Hu, Dong-Bao
AU - Shi, Wei
PY - 2024
DA - 2024/02/01 00:00:00
PB - Elsevier
SP - 20-23
VL - 59
SN - 1874-3900
SN - 1876-7486
ER -
Cite this
BibTex
Copy
@article{2024_Lin,
author = {Jia-Sheng Lin and Cuiping Zhang and Yuchun Zhu and Chunyan Zhao and Zeng-Hui Han and Dong-Bao Hu and Wei Shi},
title = {Synthesis and antifungal activity of 2,4-dihydroxy-5-methylphenyl ethanone derivatives against phytopathogenic fungi in vitro},
journal = {Phytochemistry Letters},
year = {2024},
volume = {59},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.phytol.2023.11.008},
pages = {20--23},
doi = {10.1016/j.phytol.2023.11.008}
}