In utero chronic intermittent nicotine aerosol exposure increases ischemic heart injury in adult offspring via programming of Angiotensin II receptor-derived TGFβ/ROS/Akt signaling pathway
Wansu Yu
1
,
Zewen Chen
2
,
Yong Li
3
,
Siyi Jiang
4
,
Lubo Zhang
3
,
Xuesi M Shao
5
,
Daliao Xiao
6
3
Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
|
6
Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA. Electronic address: Dxiao@llu.edu.
Publication type: Journal Article
Publication date: 2024-09-01
scimago Q2
wos Q2
SJR: 0.797
CiteScore: 5.7
Impact factor: 2.8
ISSN: 08906238, 18731708
PubMed ID:
38945500
Abstract
In utero cigarette smoking/nicotine exposure during pregnancy significantly affects fetal development and increases the risk of cardiovascular disease late in life. However, the underlying molecular mechanisms remain largely unknown. We tested the hypothesis that fetal nicotine aerosol exposure reprograms ischemia-sensitive gene expressions, resulting in increased heart susceptibility to ischemic injury and cardiac dysfunction in adulthood.
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Yu W. et al. In utero chronic intermittent nicotine aerosol exposure increases ischemic heart injury in adult offspring via programming of Angiotensin II receptor-derived TGFβ/ROS/Akt signaling pathway // Reproductive Toxicology. 2024. Vol. 128. p. 108650.
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Yu W., Chen Z., Li Y., Jiang S., Zhang L., Shao X. M., Xiao D. In utero chronic intermittent nicotine aerosol exposure increases ischemic heart injury in adult offspring via programming of Angiotensin II receptor-derived TGFβ/ROS/Akt signaling pathway // Reproductive Toxicology. 2024. Vol. 128. p. 108650.
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TY - JOUR
DO - 10.1016/j.reprotox.2024.108650
UR - https://linkinghub.elsevier.com/retrieve/pii/S0890623824001175
TI - In utero chronic intermittent nicotine aerosol exposure increases ischemic heart injury in adult offspring via programming of Angiotensin II receptor-derived TGFβ/ROS/Akt signaling pathway
T2 - Reproductive Toxicology
AU - Yu, Wansu
AU - Chen, Zewen
AU - Li, Yong
AU - Jiang, Siyi
AU - Zhang, Lubo
AU - Shao, Xuesi M
AU - Xiao, Daliao
PY - 2024
DA - 2024/09/01
PB - Elsevier
SP - 108650
VL - 128
PMID - 38945500
SN - 0890-6238
SN - 1873-1708
ER -
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@article{2024_Yu,
author = {Wansu Yu and Zewen Chen and Yong Li and Siyi Jiang and Lubo Zhang and Xuesi M Shao and Daliao Xiao},
title = {In utero chronic intermittent nicotine aerosol exposure increases ischemic heart injury in adult offspring via programming of Angiotensin II receptor-derived TGFβ/ROS/Akt signaling pathway},
journal = {Reproductive Toxicology},
year = {2024},
volume = {128},
publisher = {Elsevier},
month = {sep},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0890623824001175},
pages = {108650},
doi = {10.1016/j.reprotox.2024.108650}
}
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