Small Ruminant Research, volume 141, pages 127-134
Interleukin-2 ((IL-2) gene polymorphism and association with heat tolerance in Nigerian goats
Abdulmojeed Yakubu
1, 2, 3
,
A E Salako
3
,
Marcos De Donato
4, 5
,
M I Takeet
1, 6
,
Sunday O. Peters
7
,
M. Wheto
8
,
Moses Okpeku
9, 10
,
Ikhide G. Imumorin
1
6
Department of Veterinary Microbiology and Parasitology, University of Agriculture, Abeokuta, Nigeria
|
7
Department of Animal Science, Berry College, GA 30249, USA
|
8
Department of Animal Breeding and Genetics , University of Agriculture , Abeokuta , Nigeria
|
Publication type: Journal Article
Publication date: 2016-08-01
Journal:
Small Ruminant Research
scimago Q2
SJR: 0.494
CiteScore: 3.1
Impact factor: 1.6
ISSN: 09214488, 18790941
Animal Science and Zoology
Food Animals
Abstract
Interleukin-2 (IL-2) serves as a potent immuno-modulator, and plays a unique role in both the activation and maintenance of immune responses and in lymphocyte development. Gene polymorphism in IL-2 gene in three major Nigerian goat breeds [West African Dwarf (WAD), Red Sokoto (RS) and Sahel (SH)] was analysed by restriction fragment length polymorphisms (RFLP). The restriction enzyme, DraI was utilized. The association between the polymorphic site and some heat tolerant traits were also investigated in a total of 157 animals comprising 59 WAD, 69 RS, and 29 SH goats of both sexes. The IL-2 sequence displayed a 98% nucleotide identity with the referenced Cahi-IL-2 AY603404.1 orthologous sequence in GenBank. The phylogenetic trees revealed largely species-wise clustering, while the RS and SH goats were closer compared to the WAD goats. DraI genotype frequencies were in Hardy-Weinberg Equilibrium (P
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Yakubu A. et al. Interleukin-2 ((IL-2) gene polymorphism and association with heat tolerance in Nigerian goats // Small Ruminant Research. 2016. Vol. 141. pp. 127-134.
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Yakubu A., Salako A. E., De Donato M., Takeet M. I., Peters S. O., Wheto M., Okpeku M., Imumorin I. G. Interleukin-2 ((IL-2) gene polymorphism and association with heat tolerance in Nigerian goats // Small Ruminant Research. 2016. Vol. 141. pp. 127-134.
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TY - JOUR
DO - 10.1016/j.smallrumres.2016.07.015
UR - https://doi.org/10.1016/j.smallrumres.2016.07.015
TI - Interleukin-2 ((IL-2) gene polymorphism and association with heat tolerance in Nigerian goats
T2 - Small Ruminant Research
AU - Yakubu, Abdulmojeed
AU - Salako, A E
AU - De Donato, Marcos
AU - Takeet, M I
AU - Peters, Sunday O.
AU - Wheto, M.
AU - Okpeku, Moses
AU - Imumorin, Ikhide G.
PY - 2016
DA - 2016/08/01
PB - Elsevier
SP - 127-134
VL - 141
SN - 0921-4488
SN - 1879-0941
ER -
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@article{2016_Yakubu,
author = {Abdulmojeed Yakubu and A E Salako and Marcos De Donato and M I Takeet and Sunday O. Peters and M. Wheto and Moses Okpeku and Ikhide G. Imumorin},
title = {Interleukin-2 ((IL-2) gene polymorphism and association with heat tolerance in Nigerian goats},
journal = {Small Ruminant Research},
year = {2016},
volume = {141},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.smallrumres.2016.07.015},
pages = {127--134},
doi = {10.1016/j.smallrumres.2016.07.015}
}