Developmental Stage and Time Dictate the Fate of Wnt/β-Catenin-Responsive Stem Cells in the Mammary Gland
Publication type: Journal Article
Publication date: 2012-09-01
scimago Q1
wos Q1
SJR: 9.313
CiteScore: 32.9
Impact factor: 20.4
ISSN: 19345909, 18759777
PubMed ID:
22863533
Cell Biology
Genetics
Molecular Medicine
Abstract
The mammary epithelium undergoes extensive growth and remodeling during pregnancy, suggesting a role for stem cells. Yet their origin, identity, and behavior in the intact tissue remain unknown. Using an Axin2(CreERT2) allele, we labeled and traced Wnt/β-catenin-responsive cells throughout mammary gland development. This reveals a switch in Wnt/β-catenin signaling around birth and shows that, depending on the developmental stage, Axin2(+) cells contribute differently to basal and luminal epithelial cell lineages of the mammary epithelium. Moreover, an important difference exists between the developmental potential tested in transplantation assays and that displayed by the same cell population in situ. Finally, Axin2(+) cells in the adult build alveolar structures during multiple pregnancies, demonstrating the existence of a Wnt/β-catenin-responsive adult stem cell. Our study uncovers dynamic changes in Wnt/β-catenin signaling in the mammary epithelium and offers insights into the developmental fate of mammary gland stem and progenitor cells.
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411
Total citations:
411
Citations from 2024:
35
(8.53%)
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GOST
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van Amerongen R., Bowman A. N., Nusse R. Developmental Stage and Time Dictate the Fate of Wnt/β-Catenin-Responsive Stem Cells in the Mammary Gland // Cell Stem Cell. 2012. Vol. 11. No. 3. pp. 387-400.
GOST all authors (up to 50)
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van Amerongen R., Bowman A. N., Nusse R. Developmental Stage and Time Dictate the Fate of Wnt/β-Catenin-Responsive Stem Cells in the Mammary Gland // Cell Stem Cell. 2012. Vol. 11. No. 3. pp. 387-400.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.stem.2012.05.023
UR - https://doi.org/10.1016/j.stem.2012.05.023
TI - Developmental Stage and Time Dictate the Fate of Wnt/β-Catenin-Responsive Stem Cells in the Mammary Gland
T2 - Cell Stem Cell
AU - van Amerongen, Renée
AU - Bowman, Angela N
AU - Nusse, Roel
PY - 2012
DA - 2012/09/01
PB - Elsevier
SP - 387-400
IS - 3
VL - 11
PMID - 22863533
SN - 1934-5909
SN - 1875-9777
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_van Amerongen,
author = {Renée van Amerongen and Angela N Bowman and Roel Nusse},
title = {Developmental Stage and Time Dictate the Fate of Wnt/β-Catenin-Responsive Stem Cells in the Mammary Gland},
journal = {Cell Stem Cell},
year = {2012},
volume = {11},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.stem.2012.05.023},
number = {3},
pages = {387--400},
doi = {10.1016/j.stem.2012.05.023}
}
Cite this
MLA
Copy
van Amerongen, Renée, et al. “Developmental Stage and Time Dictate the Fate of Wnt/β-Catenin-Responsive Stem Cells in the Mammary Gland.” Cell Stem Cell, vol. 11, no. 3, Sep. 2012, pp. 387-400. https://doi.org/10.1016/j.stem.2012.05.023.