Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
Publication type: Journal Article
Publication date: 2023-03-01
scimago Q1
wos Q1
SJR: 9.313
CiteScore: 32.9
Impact factor: 20.4
ISSN: 19345909, 18759777
PubMed ID:
36764294
Cell Biology
Genetics
Molecular Medicine
Abstract
Increasing evidence implicates the critical roles of various epitranscriptomic RNA modifications in different biological processes. Methyltransferase METTL8 installs 3-methylcytosine (m3C) modification of mitochondrial tRNAs in vitro; however, its role in intact biological systems is unknown. Here, we show that Mettl8 is localized in mitochondria and installs m3C specifically on mitochondrial tRNAThr/Ser(UCN) in mouse embryonic cortical neural stem cells. At molecular and cellular levels, Mettl8 deletion in cortical neural stem cells leads to reduced mitochondrial protein translation and attenuated respiration activity. At the functional level, conditional Mettl8 deletion in mice results in impaired embryonic cortical neural stem cell maintenance in vivo, which can be rescued by pharmacologically enhancing mitochondrial functions. Similarly, METTL8 promotes mitochondrial protein expression and neural stem cell maintenance in human forebrain cortical organoids. Together, our study reveals a conserved epitranscriptomic mechanism of Mettl8 and mitochondrial tRNA m3C modification in maintaining embryonic cortical neural stem cells in mice and humans.
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Metrics
34
Total citations:
34
Citations from 2024:
26
(76.48%)
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GOST
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Zhao F. et al. Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification // Cell Stem Cell. 2023. Vol. 30. No. 3. p. 300-311.e11.
GOST all authors (up to 50)
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Zhao F., Yoon K. J., Zhang D. Y., Kim N., Ming Guo 郭., Song H. Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification // Cell Stem Cell. 2023. Vol. 30. No. 3. p. 300-311.e11.
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RIS
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TY - JOUR
DO - 10.1016/j.stem.2023.01.007
UR - https://doi.org/10.1016/j.stem.2023.01.007
TI - Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
T2 - Cell Stem Cell
AU - Zhao, Feng
AU - Yoon, Ki Jun
AU - Zhang, Daniel Y
AU - Kim, Nam-Shik
AU - Ming Guo, 郭明
AU - Song, Hongjun
PY - 2023
DA - 2023/03/01
PB - Elsevier
SP - 300-311.e11
IS - 3
VL - 30
PMID - 36764294
SN - 1934-5909
SN - 1875-9777
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Zhao,
author = {Feng Zhao and Ki Jun Yoon and Daniel Y Zhang and Nam-Shik Kim and 郭明 Ming Guo and Hongjun Song},
title = {Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification},
journal = {Cell Stem Cell},
year = {2023},
volume = {30},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.stem.2023.01.007},
number = {3},
pages = {300--311.e11},
doi = {10.1016/j.stem.2023.01.007}
}
Cite this
MLA
Copy
Zhao, Feng, et al. “Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification.” Cell Stem Cell, vol. 30, no. 3, Mar. 2023, pp. 300-311.e11. https://doi.org/10.1016/j.stem.2023.01.007.