Talanta

, volume 238 , issue Pt 1 , pages 122987

Sensitive electrochemical immunosensor for CYFRA21-1 detection based on AuNPs@MoS2@Ti3C2T composites

Kai Hu ¹

Jiamin Cheng ¹

Kangbin Wang ²

Yuanqing Zhao ¹

Yanju Liu ¹

Huaixia Yang ¹

Zhenqiang Zhang ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Henan University of Chinese Medicine, Zhengzhou, 450046, PR China. |

Henan Research Institute of Breeding Livestock and Poultry Industry Co., Ltd, Zhengzhou, 450000, PR China |

Publication type: Journal Article

Publication date: 2022-02-01

Elsevier

Talanta

scimago Q1

wos Q1

SJR: 0.976

CiteScore: 11.0

Impact factor: 6.1

ISSN: 00399140, 18733573

DOI: 10.1016/j.talanta.2021.122987

Copy DOI

PubMed ID: 34857321

Analytical Chemistry

Abstract

Cytokeratin fragment antigen 21-1 (CYFRA21-1) is a sensitive marker for detecting non-small cell lung cancer (NSCLC). Ti3C2Tx modified by gold nanoparticles (AuNPs) and molybdenum disulfide (MoS2) were synthesized for the first time to obtain the AuNPs@MoS2@Ti3C2Tx composites, which have large specific surface area and good electrocatalytic properties. A novel electrochemical immunoassay for sensitive detection of CYFRA21-1 was developed by loading a large quantity of secondary antibodies (Ab2) and toluidine blue (TB) on the surface of the material as signal probe, and Nafion-AuNPs mixture as electrode material. When the electrochemical response value of CYFRA21-1 increased linearly within the concentration range of 0.5 pg mL-1-50 ng mL-1, the detection limit can reach as low as 0.03 pg mL-1. In addition, the experimental results showed that the biosensor had the potential to rapidly detect CYFRA21-1 in the complex samples such as patient serum, and had a broad application prospect in the early diagnosis and monitoring of NSCLC.

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GOST |

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GOST Copy

Hu K. et al. Sensitive electrochemical immunosensor for CYFRA21-1 detection based on AuNPs@MoS2@Ti3C2T composites // Talanta. 2022. Vol. 238. No. Pt 1. p. 122987.

GOST all authors (up to 50) Copy

Hu K., Cheng J., Wang K., Zhao Y., Liu Y., Yang H., Zhang Z. Sensitive electrochemical immunosensor for CYFRA21-1 detection based on AuNPs@MoS2@Ti3C2T composites // Talanta. 2022. Vol. 238. No. Pt 1. p. 122987.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.talanta.2021.122987

UR - https://doi.org/10.1016/j.talanta.2021.122987

TI - Sensitive electrochemical immunosensor for CYFRA21-1 detection based on AuNPs@MoS2@Ti3C2T composites

T2 - Talanta

AU - Hu, Kai

AU - Cheng, Jiamin

AU - Wang, Kangbin

AU - Zhao, Yuanqing

AU - Liu, Yanju

AU - Yang, Huaixia

AU - Zhang, Zhenqiang

PY - 2022

DA - 2022/02/01

PB - Elsevier

SP - 122987

IS - Pt 1

VL - 238

PMID - 34857321

SN - 0039-9140

SN - 1873-3573

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2022_Hu,

author = {Kai Hu and Jiamin Cheng and Kangbin Wang and Yuanqing Zhao and Yanju Liu and Huaixia Yang and Zhenqiang Zhang},

title = {Sensitive electrochemical immunosensor for CYFRA21-1 detection based on AuNPs@MoS2@Ti3C2T composites},

journal = {Talanta},

year = {2022},

volume = {238},

publisher = {Elsevier},

month = {feb},

url = {https://doi.org/10.1016/j.talanta.2021.122987},

number = {Pt 1},

pages = {122987},

doi = {10.1016/j.talanta.2021.122987}

}

MLA

Cite this

MLA Copy

Hu, Kai, et al. “Sensitive electrochemical immunosensor for CYFRA21-1 detection based on AuNPs@MoS2@Ti3C2T composites.” Talanta, vol. 238, no. Pt 1, Feb. 2022, p. 122987. https://doi.org/10.1016/j.talanta.2021.122987.

Publisher

Elsevier

Journal

Talanta

scimago Q1

wos Q1

SJR

0.976

CiteScore

11.0

Impact factor

6.1

ISSN

00399140 (Print)

18733573 (Electronic)