A greener enantioselective synthesis of the antiviral agent North-methanocarbathymidine (N-MCT) from 2-deoxy-d-ribose
Publication type: Journal Article
Publication date: 2009-10-01
scimago Q3
wos Q2
SJR: 0.426
CiteScore: 4.1
Impact factor: 2.2
ISSN: 00404020, 14645416
PubMed ID:
20625519
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
An enantioselective synthesis of suitably protected (1R,2S,4S,5S)-4-amino-1-(hydroxymethyl)bicyclo[3.1.0]hexan-2-ol, a key starting material for the synthesis of conformationally locked carbocyclic nucleosides, including the antiviral active North-methanocarba thymidine, is reported. Starting from 2-deoxyribose the target Boc-protected amine was prepared in 33% overall yield under condition that are ecologically friendlier than previous methods.
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Total citations:
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Citations from 2024:
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(5.26%)
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GOST
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Ludek O. R., Marquez V. E. A greener enantioselective synthesis of the antiviral agent North-methanocarbathymidine (N-MCT) from 2-deoxy-d-ribose // Tetrahedron. 2009. Vol. 65. No. 41. pp. 8461-8467.
GOST all authors (up to 50)
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Ludek O. R., Marquez V. E. A greener enantioselective synthesis of the antiviral agent North-methanocarbathymidine (N-MCT) from 2-deoxy-d-ribose // Tetrahedron. 2009. Vol. 65. No. 41. pp. 8461-8467.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.tet.2009.08.035
UR - https://doi.org/10.1016/j.tet.2009.08.035
TI - A greener enantioselective synthesis of the antiviral agent North-methanocarbathymidine (N-MCT) from 2-deoxy-d-ribose
T2 - Tetrahedron
AU - Ludek, Olaf R
AU - Marquez, Victor E.
PY - 2009
DA - 2009/10/01
PB - Elsevier
SP - 8461-8467
IS - 41
VL - 65
PMID - 20625519
SN - 0040-4020
SN - 1464-5416
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2009_Ludek,
author = {Olaf R Ludek and Victor E. Marquez},
title = {A greener enantioselective synthesis of the antiviral agent North-methanocarbathymidine (N-MCT) from 2-deoxy-d-ribose},
journal = {Tetrahedron},
year = {2009},
volume = {65},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.tet.2009.08.035},
number = {41},
pages = {8461--8467},
doi = {10.1016/j.tet.2009.08.035}
}
Cite this
MLA
Copy
Ludek, Olaf R., and Victor E. Marquez. “A greener enantioselective synthesis of the antiviral agent North-methanocarbathymidine (N-MCT) from 2-deoxy-d-ribose.” Tetrahedron, vol. 65, no. 41, Oct. 2009, pp. 8461-8467. https://doi.org/10.1016/j.tet.2009.08.035.