New efficient synthesis of isoquinoline-1,3(2H,4H)-diones and isoindolin-1-ones via sequential Ugi/cyclization reaction
Publication type: Journal Article
Publication date: 2016-01-01
scimago Q3
wos Q2
SJR: 0.426
CiteScore: 4.1
Impact factor: 2.2
ISSN: 00404020, 14645416
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
A new efficient synthesis of isoquinoline-1,3(2H,4H)-diones or isoindolin-1-ones via sequential Ugi-4CR or Ugi-3CR/cyclization reaction was developed. α-Acylamino amides 5, obtained from Ugi-4CR of methyl 2-formylbenzoate, amines, isocyanates and acids, cyclized to give isoquinoline-1,3(2H,4H)-diones 6 in good yields in the presence of catalytic amount of sodium ethoxide. Ugi-3CR of methyl 2-formylbenzoate, amines and isocyanates in the presence of catalytic amount of H3PO4 produced isoindolin-1-ones 7 directly in one-pot fashion.
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Total citations:
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Citations from 2024:
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(14.28%)
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GOST
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Yuan D. et al. New efficient synthesis of isoquinoline-1,3(2H,4H)-diones and isoindolin-1-ones via sequential Ugi/cyclization reaction // Tetrahedron. 2016. Vol. 72. No. 2. pp. 338-346.
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Yuan D., Duan Z., Rao Y., Ding M. New efficient synthesis of isoquinoline-1,3(2H,4H)-diones and isoindolin-1-ones via sequential Ugi/cyclization reaction // Tetrahedron. 2016. Vol. 72. No. 2. pp. 338-346.
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RIS
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TY - JOUR
DO - 10.1016/j.tet.2015.11.051
UR - https://doi.org/10.1016/j.tet.2015.11.051
TI - New efficient synthesis of isoquinoline-1,3(2H,4H)-diones and isoindolin-1-ones via sequential Ugi/cyclization reaction
T2 - Tetrahedron
AU - Yuan, Ding
AU - Duan, Zhuan
AU - Rao, Yong
AU - Ding, Ming-Wu
PY - 2016
DA - 2016/01/01
PB - Elsevier
SP - 338-346
IS - 2
VL - 72
SN - 0040-4020
SN - 1464-5416
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Yuan,
author = {Ding Yuan and Zhuan Duan and Yong Rao and Ming-Wu Ding},
title = {New efficient synthesis of isoquinoline-1,3(2H,4H)-diones and isoindolin-1-ones via sequential Ugi/cyclization reaction},
journal = {Tetrahedron},
year = {2016},
volume = {72},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.tet.2015.11.051},
number = {2},
pages = {338--346},
doi = {10.1016/j.tet.2015.11.051}
}
Cite this
MLA
Copy
Yuan, Ding, et al. “New efficient synthesis of isoquinoline-1,3(2H,4H)-diones and isoindolin-1-ones via sequential Ugi/cyclization reaction.” Tetrahedron, vol. 72, no. 2, Jan. 2016, pp. 338-346. https://doi.org/10.1016/j.tet.2015.11.051.