Asymmetric synthesis of l-DOPA and (R)-selegiline via, OsO4-catalyzed asymmetric dihydroxylation
Publication type: Journal Article
Publication date: 2004-10-01
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Abstract
A simple and effective procedure for the enantioselective synthesis of two important neurotransmitter drugs, that is, (S)-3,4-dihydroxyphenylalanine ( l -DOPA) and (R)-N,α-dimethyl-N-2-propynylbenzeneethaneamine [(R)-selegiline], is described by employing the Sharpless asymmetric dihydroxylation (AD) as a key step to introduce chirality.
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61
Total citations:
61
Citations from 2024:
5
(8.2%)
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GOST
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Sayyed I. A., Sudalai A. Asymmetric synthesis of l-DOPA and (R)-selegiline via, OsO4-catalyzed asymmetric dihydroxylation // Tetrahedron Asymmetry. 2004. Vol. 15. No. 19. pp. 3111-3116.
GOST all authors (up to 50)
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Sayyed I. A., Sudalai A. Asymmetric synthesis of l-DOPA and (R)-selegiline via, OsO4-catalyzed asymmetric dihydroxylation // Tetrahedron Asymmetry. 2004. Vol. 15. No. 19. pp. 3111-3116.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.tetasy.2004.08.007
UR - https://doi.org/10.1016/j.tetasy.2004.08.007
TI - Asymmetric synthesis of l-DOPA and (R)-selegiline via, OsO4-catalyzed asymmetric dihydroxylation
T2 - Tetrahedron Asymmetry
AU - Sayyed, Iliyas Ali
AU - Sudalai, Arumugam
PY - 2004
DA - 2004/10/01
PB - Elsevier
SP - 3111-3116
IS - 19
VL - 15
SN - 0957-4166
SN - 1362-511X
ER -
Cite this
BibTex (up to 50 authors)
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@article{2004_Sayyed,
author = {Iliyas Ali Sayyed and Arumugam Sudalai},
title = {Asymmetric synthesis of l-DOPA and (R)-selegiline via, OsO4-catalyzed asymmetric dihydroxylation},
journal = {Tetrahedron Asymmetry},
year = {2004},
volume = {15},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.tetasy.2004.08.007},
number = {19},
pages = {3111--3116},
doi = {10.1016/j.tetasy.2004.08.007}
}
Cite this
MLA
Copy
Sayyed, Iliyas Ali, and Arumugam Sudalai. “Asymmetric synthesis of l-DOPA and (R)-selegiline via, OsO4-catalyzed asymmetric dihydroxylation.” Tetrahedron Asymmetry, vol. 15, no. 19, Oct. 2004, pp. 3111-3116. https://doi.org/10.1016/j.tetasy.2004.08.007.