Tetrahedron Letters, volume 54, issue 37, pages 5001-5003

Synthesis of 2-substituted pyrrolidines from nitriles

Publication type: Journal Article
Publication date: 2013-09-01
scimago Q3
wos Q3
SJR: 0.323
CiteScore: 3.5
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
A novel and synthetically facile production of 2-substituted pyrrolidines from commercially available nitriles is reported herein. This methodology is operationally simple, and only requires the use of an extraction and a single chromatographic purification to furnish the title compounds in high purity and very good yields.
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