Difluorocarbene enabled ester insertion/1,4-acyl rearrangement of 2-acetoxylpyridines: Modular access to gem-difluoromethylenated 2-pyridones
Publication type: Journal Article
Publication date: 2023-04-01
scimago Q3
wos Q3
SJR: 0.334
CiteScore: 3.2
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
An efficient and simple protocol for the construction of gem-difluoromethylenated 2-pyridones via difluorocarbene enabled ester insertion/acyl rearrangement of 2-acetoxylpyridines and (bromodifluoromethyl)trimethylsilane has been documented. The reactions feature transition-metal free, mild reaction conditions and excellent functional group compatibility. The late-stage modification of bioactive molecules, scaled-up reaction, and synthetic transformations demonstrated the practicability of this protocol.
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6
Total citations:
6
Citations from 2024:
5
(83.33%)
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Li S., Wang G., Ye Z. S. Difluorocarbene enabled ester insertion/1,4-acyl rearrangement of 2-acetoxylpyridines: Modular access to gem-difluoromethylenated 2-pyridones // Tetrahedron Letters. 2023. Vol. 119. p. 154413.
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Li S., Wang G., Ye Z. S. Difluorocarbene enabled ester insertion/1,4-acyl rearrangement of 2-acetoxylpyridines: Modular access to gem-difluoromethylenated 2-pyridones // Tetrahedron Letters. 2023. Vol. 119. p. 154413.
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TY - JOUR
DO - 10.1016/j.tetlet.2023.154413
UR - https://doi.org/10.1016/j.tetlet.2023.154413
TI - Difluorocarbene enabled ester insertion/1,4-acyl rearrangement of 2-acetoxylpyridines: Modular access to gem-difluoromethylenated 2-pyridones
T2 - Tetrahedron Letters
AU - Li, Shiwei
AU - Wang, Gang
AU - Ye, Zhi Shi
PY - 2023
DA - 2023/04/01
PB - Elsevier
SP - 154413
VL - 119
SN - 0040-4039
SN - 1873-3581
ER -
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@article{2023_Li,
author = {Shiwei Li and Gang Wang and Zhi Shi Ye},
title = {Difluorocarbene enabled ester insertion/1,4-acyl rearrangement of 2-acetoxylpyridines: Modular access to gem-difluoromethylenated 2-pyridones},
journal = {Tetrahedron Letters},
year = {2023},
volume = {119},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.tetlet.2023.154413},
pages = {154413},
doi = {10.1016/j.tetlet.2023.154413}
}