Mitochondrial-derived microproteins: from discovery to function
Kelvin Yen
1, 2
,
Brendan Miller
3
,
Hiroshi Kumagai
4
,
Ana Silverstein
2
,
Ana R Silverstein
4
,
Pinchas Cohen
4
Publication type: Journal Article
Publication date: 2025-02-01
scimago Q1
wos Q1
SJR: 3.928
CiteScore: 23.6
Impact factor: 16.3
ISSN: 01689525, 13624555
PubMed ID:
39690001
Abstract
Given the uniqueness of the mitochondria, and the fact that they have their own genome, mitochondrial-derived microproteins (MDPs) are similar to, but different from, nuclear-encoded microproteins. The discovery of an increasing number of microproteins from this organelle and the importance of mitochondria to cellular and organismal health make it a priority to study this novel class of proteins in search of possible therapeutic targets and cures. In this review, we discuss the history of MDP discovery, describe the function of each MDP, and conclude with future goals and techniques to help discover more MDPs.
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8
Total citations:
8
Citations from 2024:
8
(100%)
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GOST
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Yen K. et al. Mitochondrial-derived microproteins: from discovery to function // Trends in Genetics. 2025. Vol. 41. No. 2. pp. 132-145.
GOST all authors (up to 50)
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Yen K., Miller B., Kumagai H., Silverstein A., Silverstein A. R., Cohen P. Mitochondrial-derived microproteins: from discovery to function // Trends in Genetics. 2025. Vol. 41. No. 2. pp. 132-145.
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RIS
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TY - JOUR
DO - 10.1016/j.tig.2024.11.010
UR - https://linkinghub.elsevier.com/retrieve/pii/S0168952524002920
TI - Mitochondrial-derived microproteins: from discovery to function
T2 - Trends in Genetics
AU - Yen, Kelvin
AU - Miller, Brendan
AU - Kumagai, Hiroshi
AU - Silverstein, Ana
AU - Silverstein, Ana R
AU - Cohen, Pinchas
PY - 2025
DA - 2025/02/01
PB - Elsevier
SP - 132-145
IS - 2
VL - 41
PMID - 39690001
SN - 0168-9525
SN - 1362-4555
ER -
Cite this
BibTex (up to 50 authors)
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@article{2025_Yen,
author = {Kelvin Yen and Brendan Miller and Hiroshi Kumagai and Ana Silverstein and Ana R Silverstein and Pinchas Cohen},
title = {Mitochondrial-derived microproteins: from discovery to function},
journal = {Trends in Genetics},
year = {2025},
volume = {41},
publisher = {Elsevier},
month = {feb},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0168952524002920},
number = {2},
pages = {132--145},
doi = {10.1016/j.tig.2024.11.010}
}
Cite this
MLA
Copy
Yen, Kelvin, et al. “Mitochondrial-derived microproteins: from discovery to function.” Trends in Genetics, vol. 41, no. 2, Feb. 2025, pp. 132-145. https://linkinghub.elsevier.com/retrieve/pii/S0168952524002920.