Preparation of phenylephrine 3-O-sulfate as the major in vivo metabolite of phenylephrine to facilitate its pharmacokinetic and metabolism studies
Тип публикации: Journal Article
Дата публикации: 2019-01-01
scimago Q3
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БС2
SJR: 0.461
CiteScore: 2.8
Impact factor: 1.8
ISSN: 10568719, 1873488X
PubMed ID:
30502391
Pharmacology
Toxicology
Краткое описание
The in vivo disposition and metabolism of phenylephrine have not been establishedby previous analytical methods and there is a lack of available standards for quantitating the metabolites.We pursued and compared the preparation of sulfation metabolites of phenylephrine and its ethyl analog etilefrine via chemical and bio-synthesis.Both sulfates were obtained in higher yield and purity through chemical syntheses compared to biosynthesis.A facile method for the production of phenylephrine 3-O-sulfate and etilefrine 3-O-sulfate was established. These compounds will be useful in the development of analytical assays for studying the pharmacokinetics of phenylephrine and its main route of metabolism in the presence of formulation changes and pharmacogenetic variation.
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Journal of Chemical Technology and Biotechnology
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Zhang C., Zhang Y., Gerk P. M. Preparation of phenylephrine 3-O-sulfate as the major in vivo metabolite of phenylephrine to facilitate its pharmacokinetic and metabolism studies // Journal of Pharmacological and Toxicological Methods. 2019. Vol. 95. pp. 66-69.
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Zhang C., Zhang Y., Gerk P. M. Preparation of phenylephrine 3-O-sulfate as the major in vivo metabolite of phenylephrine to facilitate its pharmacokinetic and metabolism studies // Journal of Pharmacological and Toxicological Methods. 2019. Vol. 95. pp. 66-69.
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TY - JOUR
DO - 10.1016/j.vascn.2018.11.009
UR - https://doi.org/10.1016/j.vascn.2018.11.009
TI - Preparation of phenylephrine 3-O-sulfate as the major in vivo metabolite of phenylephrine to facilitate its pharmacokinetic and metabolism studies
T2 - Journal of Pharmacological and Toxicological Methods
AU - Zhang, Cankui
AU - Zhang, Yan
AU - Gerk, Phillip M.
PY - 2019
DA - 2019/01/01
PB - Elsevier
SP - 66-69
VL - 95
PMID - 30502391
SN - 1056-8719
SN - 1873-488X
ER -
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@article{2019_Zhang,
author = {Cankui Zhang and Yan Zhang and Phillip M. Gerk},
title = {Preparation of phenylephrine 3-O-sulfate as the major in vivo metabolite of phenylephrine to facilitate its pharmacokinetic and metabolism studies},
journal = {Journal of Pharmacological and Toxicological Methods},
year = {2019},
volume = {95},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.vascn.2018.11.009},
pages = {66--69},
doi = {10.1016/j.vascn.2018.11.009}
}