Veterinary Microbiology, volume 247, pages 108784
Full-genome analysis and pathogenicity of a genetically distinct Russian PRRSV-1 Tyu16 strain
Yuzhakov Anton
1
,
Raev Sergei A
2
,
Shchetinin Alexey M
3
,
Гущин В. А.
4
,
Alekseev Konstantin P.
5
,
Stafford Viсtoria V
6
,
Komina Alina K
7
,
Zaberezhny Alexei D
8
,
Gulyukin Alexey M
9
,
Aliper T.I
10
Publication type: Journal Article
Publication date: 2020-08-01
Journal:
Veterinary Microbiology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 3.3
ISSN: 03781135, 18732542
General Medicine
Microbiology
General Veterinary
Abstract
Porcine reproductive and respiratory syndrome virus-1 (PRRSV-1) strains from Eastern Europe have a high diversity. All three known subtypes (1, 2, 3) of PRRSV-1 have been detected in Russia. There are two different groups of viruses belonging to the subtype 1: pan-European subtype 1 strains, and insufficiently studied Russian strains. The main objective of this study was to characterize the full genomic structure of the atypical Tyu16 strain of the Russian group subtype 1 PRRSV-1 and to assess its pathogenicity. Complete sequencing of the Tyu16 strain revealed that it did not belong to any existing subtype. Comparison of the whole genome sequence of the Tyu16 strain with that of PRRSV-1 prototype strains revealed 78.1 % (subtype 1 Lelystad), 78.1 % (subtype 2 WestSib13) and 77.7 % (subtype 3 Lena) nucleotide identity level, respectively. The coding sequence of different parts of the Tyu16 strain genome demonstrated a varying percentage identity to the different reference PRRSV-1 strains, which may indicate recombination events in its evolutionary history. We assume that among PRRSV-1 isolates, the Tyu16 is the closest relative to the common ancestor of PRRSV-1 and PRRSV-2. Low pathogenicity of the Tyu16 was demonstrated by experimental infection of 70-day-old piglets. Infected animals showed fever not exceeding 7 days, dyspnea in two out of five pigs and reduced weight gain. The virus shedding was undetectable and viremia was at low level.
Citations by journals
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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3 publications, 37.5%
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1 publication, 12.5%
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1
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Yuzhakov A. et al. Full-genome analysis and pathogenicity of a genetically distinct Russian PRRSV-1 Tyu16 strain // Veterinary Microbiology. 2020. Vol. 247. p. 108784.
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Yuzhakov A., Raev S. A., Shchetinin A. M., Гущин В. А., Alekseev K. P., Stafford V. V., Komina A. K., Zaberezhny A. D., Gulyukin A. M., Aliper T. Full-genome analysis and pathogenicity of a genetically distinct Russian PRRSV-1 Tyu16 strain // Veterinary Microbiology. 2020. Vol. 247. p. 108784.
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TY - JOUR
DO - 10.1016/j.vetmic.2020.108784
UR - https://doi.org/10.1016%2Fj.vetmic.2020.108784
TI - Full-genome analysis and pathogenicity of a genetically distinct Russian PRRSV-1 Tyu16 strain
T2 - Veterinary Microbiology
AU - Yuzhakov, Anton
AU - Raev, Sergei A
AU - Shchetinin, Alexey M
AU - Гущин, В. А.
AU - Alekseev, Konstantin P.
AU - Stafford, Viсtoria V
AU - Komina, Alina K
AU - Zaberezhny, Alexei D
AU - Gulyukin, Alexey M
AU - Aliper, T.I
PY - 2020
DA - 2020/08/01 00:00:00
PB - Elsevier
SP - 108784
VL - 247
SN - 0378-1135
SN - 1873-2542
ER -
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@article{2020_Yuzhakov,
author = {Anton Yuzhakov and Sergei A Raev and Alexey M Shchetinin and В. А. Гущин and Konstantin P. Alekseev and Viсtoria V Stafford and Alina K Komina and Alexei D Zaberezhny and Alexey M Gulyukin and T.I Aliper},
title = {Full-genome analysis and pathogenicity of a genetically distinct Russian PRRSV-1 Tyu16 strain},
journal = {Veterinary Microbiology},
year = {2020},
volume = {247},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016%2Fj.vetmic.2020.108784},
pages = {108784},
doi = {10.1016/j.vetmic.2020.108784}
}
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