Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications
Brendan Miller
1
,
Su-Jeong Kim*
1
,
Hiroshi Kumagai
2, 3
,
Hemal P. Mehta
1
,
王翔 Wang Xiang
1
,
Jiali Liu
1
,
Kelvin Yen
1
,
Pinchas Cohen
1
Publication type: Journal Article
Publication date: 2020-08-01
scimago Q2
wos Q2
SJR: 1.012
CiteScore: 6.2
Impact factor: 3.5
ISSN: 00144827, 10902422
PubMed ID:
32387288
Cell Biology
Abstract
Mitochondrial-derived peptides (MDPs) are a novel class of bioactive microproteins that modify cell metabolism. The the eight MDPs that been characterized (e.g., humanin, MOTS-c, SHLPs1-6) attenuate disease pathology including Alzheimer's disease, prostate cancer, macular degeneration, cardiovascular disease, and diabetes. The association between disease and human genetic variation in MDPs is underexplored, although two polymorphisms in humanin and MOTS-c associate with cognitive decline and diabetes, respectively, suggesting a precise role for MDPs in disease-modification. There could be hundreds of additional MDPs that have yet to be discovered. Altogether, MDPs could explain unanswered biological and metabolic questions and are part of a growing field of novel microproteins encoded by small open reading frames. In this review, the current state of MDPs are summarized with an emphasis on biological and therapeutic implications.
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62
Total citations:
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Citations from 2024:
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(36.06%)
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GOST
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Miller B. et al. Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications // Experimental Cell Research. 2020. Vol. 393. No. 2. p. 112056.
GOST all authors (up to 50)
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Miller B., Kim* S., Kumagai H., Mehta H. P., Wang Xiang 王., Liu J., Yen K., Cohen P. Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications // Experimental Cell Research. 2020. Vol. 393. No. 2. p. 112056.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.yexcr.2020.112056
UR - https://doi.org/10.1016/j.yexcr.2020.112056
TI - Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications
T2 - Experimental Cell Research
AU - Miller, Brendan
AU - Kim*, Su-Jeong
AU - Kumagai, Hiroshi
AU - Mehta, Hemal P.
AU - Wang Xiang, 王翔
AU - Liu, Jiali
AU - Yen, Kelvin
AU - Cohen, Pinchas
PY - 2020
DA - 2020/08/01
PB - Elsevier
SP - 112056
IS - 2
VL - 393
PMID - 32387288
SN - 0014-4827
SN - 1090-2422
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Miller,
author = {Brendan Miller and Su-Jeong Kim* and Hiroshi Kumagai and Hemal P. Mehta and 王翔 Wang Xiang and Jiali Liu and Kelvin Yen and Pinchas Cohen},
title = {Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications},
journal = {Experimental Cell Research},
year = {2020},
volume = {393},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.yexcr.2020.112056},
number = {2},
pages = {112056},
doi = {10.1016/j.yexcr.2020.112056}
}
Cite this
MLA
Copy
Miller, Brendan, et al. “Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications.” Experimental Cell Research, vol. 393, no. 2, Aug. 2020, p. 112056. https://doi.org/10.1016/j.yexcr.2020.112056.