Optical Fiber Technology

, volume 80 , pages 103468

A polydopamine nanospheres modified fiber optic SPR biosensor for specific detection of C-reactive protein

Guangxiao Cao ^{1, 2}

Pengxiang Chang ^{1, 2, 3}

Ailing Zhang ^{1, 2}

Zhihong Liu ^{1, 2}

Honggang Pan ^{1, 2}

Junfeng Wang ^{1, 2}

Sihang Lin ^{1, 2}

Tengfei Yang ^{1, 2}

Hide authors affiliations Show authors affiliations: 3 affiliations

Tianjin Key Laboratory of Thin Film Electronics and Communication Devices, Tianjin 300384, China |

Tianjin University of Technology, Tianjin 300384, China |

National Key Laboratory of Electromagnetic Space Security, Tianjin 300308, China |

Publication type: Journal Article

Publication date: 2023-10-01

Elsevier

Optical Fiber Technology

scimago Q2

wos Q2

SJR: 0.565

CiteScore: 4.9

Impact factor: 2.7

ISSN: 10685200, 10959912

DOI: 10.1016/j.yofte.2023.103468

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Electronic, Optical and Magnetic Materials

Atomic and Molecular Physics, and Optics

Electrical and Electronic Engineering

Instrumentation

Control and Systems Engineering

Abstract

C-reactive protein (CRP) is a vital inflammatory marker in humans and a key single marker of cardiovascular diseases. In this paper, the concentration of CRP was specifically detected by a polydopamine nanospheres (PDA-NPs) developed surface plasmon resonance (SPR) sensor with high accuracy. PDA-NPs is a self-polymerizing material that can be obtained from dopamine through the mussel adhesion effect. The PDA-NPs (diameter ≈ 100 nm) modified SPR sensor exhibits enhanced refractive index (RI) sensitivity and bio-sensitivity attributed to the large specific surface area and high surface reactivity of the PDA-NPs. The developed sensor demonstrates a RI sensitivity of 2427.68 nm/RIU, presenting a 55.7% increase compared to the raw sensor (RI sensitivity was 1559.08 nm/RIU). Moreover, the developed biosensor is used to detect CRP specifically. The bio-sensitivity reaches 0.09 nm/(µg/mL), while the limit of detection (LOD) reaches 0.22 µg/mL. These findings indicate that the developed biosensor can specifically detect CRP with a low LOD. Therefore, this PDA-NPs modified biosensor has great potential in clinical detection and other bio-detection filed.

Found

1 citation

Hu Wenjun

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48 publications, 828 citations, 6 reviews

h-index: 16

Huazhong University of Science and Technology

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GOST Copy

Cao G. et al. A polydopamine nanospheres modified fiber optic SPR biosensor for specific detection of C-reactive protein // Optical Fiber Technology. 2023. Vol. 80. p. 103468.

GOST all authors (up to 50) Copy

Cao G., Chang P., Zhang A., Liu Z., Pan H., Wang J., Lin S., Yang T. A polydopamine nanospheres modified fiber optic SPR biosensor for specific detection of C-reactive protein // Optical Fiber Technology. 2023. Vol. 80. p. 103468.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.yofte.2023.103468

UR - https://doi.org/10.1016/j.yofte.2023.103468

TI - A polydopamine nanospheres modified fiber optic SPR biosensor for specific detection of C-reactive protein

T2 - Optical Fiber Technology

AU - Cao, Guangxiao

AU - Chang, Pengxiang

AU - Zhang, Ailing

AU - Liu, Zhihong

AU - Pan, Honggang

AU - Wang, Junfeng

AU - Lin, Sihang

AU - Yang, Tengfei

PY - 2023

DA - 2023/10/01

PB - Elsevier

SP - 103468

VL - 80

SN - 1068-5200

SN - 1095-9912

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2023_Cao,

author = {Guangxiao Cao and Pengxiang Chang and Ailing Zhang and Zhihong Liu and Honggang Pan and Junfeng Wang and Sihang Lin and Tengfei Yang},

title = {A polydopamine nanospheres modified fiber optic SPR biosensor for specific detection of C-reactive protein},

journal = {Optical Fiber Technology},

year = {2023},

volume = {80},

publisher = {Elsevier},

month = {oct},

url = {https://doi.org/10.1016/j.yofte.2023.103468},

pages = {103468},

doi = {10.1016/j.yofte.2023.103468}

}

Publisher

Elsevier

Journal

Optical Fiber Technology

scimago Q2

wos Q2

SJR

0.565

CiteScore

4.9

Impact factor

2.7

ISSN

10685200 (Print)

10959912 (Electronic)