Analytica Chimica Acta, volume 429, issue 2, pages 287-292
New technique for diagnosis and monitoring of alcaptonuria: quantification of homogentisic acid in urine with mid-infrared spectrometry
A.Patrick J.A. Markus
1
,
DORINE W. SWINKELS
1
,
Bernadette S. Jakobs
1
,
R. Wevers
2
,
J.M.Frans Trijbels
2
,
Hans L. Willems
1
1
Department of Clinical Chemistry/CKCL, University Medical Centre, Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
|
2
Laboratory of Paediatrics and Neurology, University Medical Centre, Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
|
Publication type: Journal Article
Publication date: 2001-02-01
Journal:
Analytica Chimica Acta
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.2
ISSN: 00032670, 18734324
Biochemistry
Spectroscopy
Analytical Chemistry
Environmental Chemistry
Abstract
For the first time we used Fourier transform-infra-red (FT-IR) spectrometry in the investigation of an inborn error of metabolism, i.e. alcaptonuria, which expresses itself by the excretion of high concentrations of homogentisic acid in urine. The 200 homogentisic acid-spiked urine samples, ranging from 0 to 60 mmol l−1, were analysed in the mid-IR region using an attenuated total reflection accessory. Quantification is performed with partial least squares regression analysis. The standard errors of calibration, cross validation and prediction in the IR-predicted homogentisic acid concentration are 0.64, 0.78 and 0.79 mmol l−1, respectively, with R2>0.998. The 2σ detection limit is 2.0 mmol l−1 and the intra- and inter-assay coefficients of variation are below 5% for three concentration levels. The clear difference in the concentrations of homogentisic acid in the urine of four alcaptonuria patients compared to seven control samples demonstrates the potential suitability of IR analysis for the diagnosis and monitoring of alcaptonuria patients.
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- We do not take into account publications without a DOI.
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Markus A. J. et al. New technique for diagnosis and monitoring of alcaptonuria: quantification of homogentisic acid in urine with mid-infrared spectrometry // Analytica Chimica Acta. 2001. Vol. 429. No. 2. pp. 287-292.
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Markus A. J., SWINKELS D. W., Jakobs B. S., Wevers R., Trijbels J., Willems H. L. New technique for diagnosis and monitoring of alcaptonuria: quantification of homogentisic acid in urine with mid-infrared spectrometry // Analytica Chimica Acta. 2001. Vol. 429. No. 2. pp. 287-292.
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TY - JOUR
DO - 10.1016/s0003-2670(00)01286-1
UR - https://doi.org/10.1016/s0003-2670(00)01286-1
TI - New technique for diagnosis and monitoring of alcaptonuria: quantification of homogentisic acid in urine with mid-infrared spectrometry
T2 - Analytica Chimica Acta
AU - Markus, A.Patrick J.A.
AU - SWINKELS, DORINE W.
AU - Jakobs, Bernadette S.
AU - Wevers, R.
AU - Trijbels, J.M.Frans
AU - Willems, Hans L.
PY - 2001
DA - 2001/02/01 00:00:00
PB - Elsevier
SP - 287-292
IS - 2
VL - 429
SN - 0003-2670
SN - 1873-4324
ER -
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@article{2001_Markus,
author = {A.Patrick J.A. Markus and DORINE W. SWINKELS and Bernadette S. Jakobs and R. Wevers and J.M.Frans Trijbels and Hans L. Willems},
title = {New technique for diagnosis and monitoring of alcaptonuria: quantification of homogentisic acid in urine with mid-infrared spectrometry},
journal = {Analytica Chimica Acta},
year = {2001},
volume = {429},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/s0003-2670(00)01286-1},
number = {2},
pages = {287--292},
doi = {10.1016/s0003-2670(00)01286-1}
}
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Markus, A.Patrick J.A., et al. “New technique for diagnosis and monitoring of alcaptonuria: quantification of homogentisic acid in urine with mid-infrared spectrometry.” Analytica Chimica Acta, vol. 429, no. 2, Feb. 2001, pp. 287-292. https://doi.org/10.1016/s0003-2670(00)01286-1.