High-performance liquid chromatography and gas-liquid chromatography of some norgestrel intermediates
1
Institute for Drug Research, Szabadságharcosok utja 47–49, 1045 Budapest 4 Hungary
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Publication type: Journal Article
Publication date: 1980-04-01
scimago Q1
wos Q1
SJR: 0.731
CiteScore: 7.3
Impact factor: 4.0
ISSN: 00219673, 18733778
Organic Chemistry
Biochemistry
General Medicine
Analytical Chemistry
Abstract
High-performance liquid chromatographic (HPLC) and gas-liquid chromatographic (GLC) separations of some steroidal α,β-unsaturated ketoximes, intermediates in the synthesis of the oral contraceptive norgestrel, were investigated. When GLC (trimethylsilyl derivatives) or reversed-phase HPLC was used, the syn- and anti-isomers were not resolved. However, with the syn/anti ratio changing markedly in the samples, these methods (especially reversed-phase HPLC) proved to be less accurate because the physical properties relevant to detection were different for the isomers examined. Improved accuracy can be achieved by using normal-phase HPLC and taking the corresponding isolated syn- and anti-isomers as reference standards.
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Patthy M., Tomori E. High-performance liquid chromatography and gas-liquid chromatography of some norgestrel intermediates // Journal of Chromatography A. 1980. Vol. 191. pp. 145-154.
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Patthy M., Tomori E. High-performance liquid chromatography and gas-liquid chromatography of some norgestrel intermediates // Journal of Chromatography A. 1980. Vol. 191. pp. 145-154.
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TY - JOUR
DO - 10.1016/s0021-9673(00)86374-8
UR - https://doi.org/10.1016/s0021-9673(00)86374-8
TI - High-performance liquid chromatography and gas-liquid chromatography of some norgestrel intermediates
T2 - Journal of Chromatography A
AU - Patthy, Miklós
AU - Tomori, Eva
PY - 1980
DA - 1980/04/01
PB - Elsevier
SP - 145-154
VL - 191
SN - 0021-9673
SN - 1873-3778
ER -
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@article{1980_Patthy,
author = {Miklós Patthy and Eva Tomori},
title = {High-performance liquid chromatography and gas-liquid chromatography of some norgestrel intermediates},
journal = {Journal of Chromatography A},
year = {1980},
volume = {191},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/s0021-9673(00)86374-8},
pages = {145--154},
doi = {10.1016/s0021-9673(00)86374-8}
}