Biotransformation of (−)- and (+)-isopinocampheol by three fungi

The biotransformation of (−)-isopinocampheol and (+) -isopinocampheol by Glomerella cingulata has been studied. Both substrates were converted to three pinanediols, respectively. The major metabolic products obtained were diols. The main product of (−)-isopinocampheol was (1 R , 2 R , 3 S , 4 S , 5 R )-3,4-pinanediol, and that of the (+)-enantiomer was (1 S , 2 S , 3 S , 5 R , 7 R) -3,7-pinanediol. These results confirmed that the oxidation by G. cingulata took place with enantioselectivity. In addition, the same substrates were also converted by other fungi such as Rhizoctonia solani and Aspergillus niger . Some similarities exist between the main products of the metabolism of R. solani , while those of A. niger were somewhat different. © 1997 Elsevier Science Ltd. All rights reserved