Synthesis of (3α,7β,17α)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol, a metabolite of ORG OD14, and its 7-epimer
1
Medicinal Chemistry Department, N.V. Organon, P.O. Box 20, 5340, BH Oss, The Netherlands.
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Publication type: Journal Article
Publication date: 2000-09-01
scimago Q2
wos Q3
SJR: 0.620
CiteScore: 4.3
Impact factor: 2.3
ISSN: 0039128X, 18785867
PubMed ID:
10978728
Organic Chemistry
Biochemistry
Molecular Biology
Pharmacology
Clinical Biochemistry
Endocrinology
Abstract
The syntheses of the 7beta-hydroxy metabolite of ORG OD14 (Livial), (3alpha,7beta, 17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-t riol (35), and its 7-epimer, (3alpha,7alpha, 17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-t riol (11), are described.
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Plate R. et al. Synthesis of (3α,7β,17α)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol, a metabolite of ORG OD14, and its 7-epimer // Steroids. 2000. Vol. 65. No. 9. pp. 497-504.
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Plate R., van Wuijtswinkel R. C., Jans C. G., Groen M. B. Synthesis of (3α,7β,17α)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol, a metabolite of ORG OD14, and its 7-epimer // Steroids. 2000. Vol. 65. No. 9. pp. 497-504.
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TY - JOUR
DO - 10.1016/s0039-128x(00)00110-0
UR - https://doi.org/10.1016/s0039-128x(00)00110-0
TI - Synthesis of (3α,7β,17α)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol, a metabolite of ORG OD14, and its 7-epimer
T2 - Steroids
AU - Plate, Ralf
AU - van Wuijtswinkel, Rob C.A.L.
AU - Jans, Christan G.J.M
AU - Groen, Marinus B
PY - 2000
DA - 2000/09/01
PB - Elsevier
SP - 497-504
IS - 9
VL - 65
PMID - 10978728
SN - 0039-128X
SN - 1878-5867
ER -
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@article{2000_Plate,
author = {Ralf Plate and Rob C.A.L. van Wuijtswinkel and Christan G.J.M Jans and Marinus B Groen},
title = {Synthesis of (3α,7β,17α)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol, a metabolite of ORG OD14, and its 7-epimer},
journal = {Steroids},
year = {2000},
volume = {65},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/s0039-128x(00)00110-0},
number = {9},
pages = {497--504},
doi = {10.1016/s0039-128x(00)00110-0}
}
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MLA
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Plate, Ralf, et al. “Synthesis of (3α,7β,17α)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol, a metabolite of ORG OD14, and its 7-epimer.” Steroids, vol. 65, no. 9, Sep. 2000, pp. 497-504. https://doi.org/10.1016/s0039-128x(00)00110-0.