Steroids, volume 65, issue 9, pages 497-504

Synthesis of (3α,7β,17α)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol, a metabolite of ORG OD14, and its 7-epimer

Ralf Plate 1
, 
Rob C.A.L. van Wuijtswinkel 1
, 
Christan G.J.M Jans 1
, 
Marinus B Groen 1
1
 
Medicinal Chemistry Department, N.V. Organon, P.O. Box 20, 5340, BH Oss, The Netherlands. | 
Publication type: Journal Article
Publication date: 2000-09-01
Journal: Steroids
scimago Q2
wos Q3
SJR: 0.476
CiteScore: 5.1
Impact factor: 2.1
ISSN: 0039128X, 18785867
Organic Chemistry
Biochemistry
Molecular Biology
Pharmacology
Clinical Biochemistry
Endocrinology
Abstract
The syntheses of the 7beta-hydroxy metabolite of ORG OD14 (Livial), (3alpha,7beta, 17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-t riol (35), and its 7-epimer, (3alpha,7alpha, 17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-t riol (11), are described.
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