Talanta, volume 52, issue 5, pages 873-877

Radiosensitivity study of cefazolin sodium

A Crucq

Publication type: Journal Article

Publication date: 2000-08-16

Elsevier

Journal: Talanta

Quartile SCImago

Quartile WOS

Impact factor: 6.1

ISSN: 00399140, 18733573

DOI: 10.1016/s0039-9140(00)00432-x

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Analytical Chemistry

Abstract

The extent of physico-chemical changes induced by irradiation of cefazolin sodium was investigated. The methods used were potency determination, impurity profile, colour measurements and pH measurements. The potency of irradiated samples at 25 kGy was 4+/-2% lower than that of the non irradiated ones. The total amount of related substances increased from 0.72+/-0.01% in the non irradiated samples to 4.9+/-0.7% in the samples irradiated at 25 kGy. Most of the peaks showed trace amounts (<0.01%), the largest one represented 1.2+/-0.5% of the total related substances. Only two peaks were identified by chromatography: the methyl-1,2,3-thiazol-2 thiol-5 and the 7-aminocephalosporanic acid. The latter related substance is only produced by the irradiation of cefazolin sodium. The pH values of the samples were within the specifications of the European Pharmacopoeia. The colour of the cefazolin sodium powder changed from white to yellow upon irradiation. The yellow colour persisted after the dissolution of the powder. Most of the tests carried out met the Pharmacopoeia's specifications, except the one concerning the colour of the solution.

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Crucq A. Radiosensitivity study of cefazolin sodium // Talanta. 2000. Vol. 52. No. 5. pp. 873-877.

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Crucq A. Radiosensitivity study of cefazolin sodium // Talanta. 2000. Vol. 52. No. 5. pp. 873-877.

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TY - JOUR

DO - 10.1016/s0039-9140(00)00432-x

UR - https://doi.org/10.1016/s0039-9140(00)00432-x

TI - Radiosensitivity study of cefazolin sodium

T2 - Talanta

AU - Crucq, A

PY - 2000

DA - 2000/08/16 00:00:00

PB - Elsevier

SP - 873-877

IS - 5

VL - 52

SN - 0039-9140

SN - 1873-3573

ER -

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@article{2000_Crucq,

author = {A Crucq},

title = {Radiosensitivity study of cefazolin sodium},

journal = {Talanta},

year = {2000},

volume = {52},

publisher = {Elsevier},

month = {aug},

url = {https://doi.org/10.1016/s0039-9140(00)00432-x},

number = {5},

pages = {873--877},

doi = {10.1016/s0039-9140(00)00432-x}

}

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Crucq, A.. “Radiosensitivity study of cefazolin sodium.” Talanta, vol. 52, no. 5, Aug. 2000, pp. 873-877. https://doi.org/10.1016/s0039-9140(00)00432-x.

Found error?

Publisher

Elsevier

Journal

Talanta

Quartile SCImago

Quartile WOS

Impact factor

6.1

ISSN

00399140 (Print)
18733573 (Electronic)