Tetrahedron Letters, volume 32, issue 39, pages 5349-5352
Asymmetric amination of carboxylic acids via a diels-alder strategy.
L. Ghosez
1
Publication type: Journal Article
Publication date: 1991-09-01
Journal:
Tetrahedron Letters
scimago Q3
wos Q3
SJR: 0.323
CiteScore: 3.5
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
2-azadienes 1 which are readily prepared from acyl chlorides react with high facial selectivity with the chiral carbamoyl nitroso dicnophile 2. Reduction and hydrolysis of the adducts yield enantiomerically pure amino acids.
Found
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