Tetrahedron Letters, volume 32, issue 39, pages 5349-5352

Asymmetric amination of carboxylic acids via a diels-alder strategy.

Publication typeJournal Article
Publication date1991-09-01
scimago Q3
wos Q3
SJR0.323
CiteScore3.5
Impact factor1.5
ISSN00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
2-azadienes 1 which are readily prepared from acyl chlorides react with high facial selectivity with the chiral carbamoyl nitroso dicnophile 2. Reduction and hydrolysis of the adducts yield enantiomerically pure amino acids.
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