Tetrahedron Letters, volume 39, issue 32, pages 5755-5758
Asymmetric synthesis of 2,4-disubstituted pyrrolidines
Qian Wang
1
,
N.André Sasaki
1
,
Pierre Potier
1
1
Institut de chimie des substances naturelles, CNRS 91198-Gif-sur-Yvette, France
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Publication type: Journal Article
Publication date: 1998-08-01
Journal:
Tetrahedron Letters
scimago Q3
wos Q3
SJR: 0.323
CiteScore: 3.5
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
A new strategy for asymmetric synthesis of 2,4-disubstituted pyrrolidines is described, starting from readily available chiral building blocks 1 and (2 R )-2,3- O -isopropylideneglycealdehyde ( 6 ). An efficient synthesis of enentiomerically pure compounds 2 and 3 was developed starting from chiral synthon 1
Found
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