volume 21 issue 1 pages 1-7

Investigation of the chemical equivalence of the trypanocidal products, Samorin® and Veridium®

Publication typeJournal Article
Publication date1999-10-01
scimago Q2
wos Q2
SJR0.628
CiteScore6.4
Impact factor3.1
ISSN07317085, 1873264X
Drug Discovery
Spectroscopy
Pharmaceutical Science
Clinical Biochemistry
Analytical Chemistry
Abstract
A procedure for the evaluation of chemical equivalence of proprietary formulations of isometamidium is described. The method combines the analysis of the principal component (isometamidium), HPLC profiling of related substances and determination of the inorganic impurity, ammonium chloride, using a modification of the Berthelot (Indophenol) reaction. Application of these procedures to analyses of commercially available sachets from four different batches of Samorin and four different batches of Veridium has demonstrated that there are marked qualitative and quantitative differences between batches from these two sources. Whilst Samorin samples showed inter-batch consistency of composition, there was considerable inter-batch variation between the samples of Veridium.
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GOST Copy
Tettey J. et al. Investigation of the chemical equivalence of the trypanocidal products, Samorin® and Veridium® // Journal of Pharmaceutical and Biomedical Analysis. 1999. Vol. 21. No. 1. pp. 1-7.
GOST all authors (up to 50) Copy
Tettey J., SKELLERN G. G., Grant M. B., Midgley J. M. Investigation of the chemical equivalence of the trypanocidal products, Samorin® and Veridium® // Journal of Pharmaceutical and Biomedical Analysis. 1999. Vol. 21. No. 1. pp. 1-7.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/s0731-7085(99)00110-7
UR - https://doi.org/10.1016/s0731-7085(99)00110-7
TI - Investigation of the chemical equivalence of the trypanocidal products, Samorin® and Veridium®
T2 - Journal of Pharmaceutical and Biomedical Analysis
AU - Tettey, J.N.A
AU - SKELLERN, G. G.
AU - Grant, Maria B.
AU - Midgley, J M
PY - 1999
DA - 1999/10/01
PB - Elsevier
SP - 1-7
IS - 1
VL - 21
PMID - 10701907
SN - 0731-7085
SN - 1873-264X
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{1999_Tettey,
author = {J.N.A Tettey and G. G. SKELLERN and Maria B. Grant and J M Midgley},
title = {Investigation of the chemical equivalence of the trypanocidal products, Samorin® and Veridium®},
journal = {Journal of Pharmaceutical and Biomedical Analysis},
year = {1999},
volume = {21},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/s0731-7085(99)00110-7},
number = {1},
pages = {1--7},
doi = {10.1016/s0731-7085(99)00110-7}
}
MLA
Cite this
MLA Copy
Tettey, J.N.A, et al. “Investigation of the chemical equivalence of the trypanocidal products, Samorin® and Veridium®.” Journal of Pharmaceutical and Biomedical Analysis, vol. 21, no. 1, Oct. 1999, pp. 1-7. https://doi.org/10.1016/s0731-7085(99)00110-7.