Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists
Publication type: Journal Article
Publication date: 2000-06-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
10890168
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A short synthesis of the NMDA receptor antagonist (rac)-Eliprodil (9) and its resolution into the enantiomers by chiral HPLC is described. The enantiomers (R)-9 and (S)-9 were found to exhibit markedly different affinities for NR2B subunit containing NMDA receptors.
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19
Total citations:
19
Citations from 2024:
2
(10.53%)
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MLA
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GOST
Copy
Pabel J., Höfner G., Wanner K. T. Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists // Bioorganic and Medicinal Chemistry Letters. 2000. Vol. 10. No. 12. pp. 1377-1380.
GOST all authors (up to 50)
Copy
Pabel J., Höfner G., Wanner K. T. Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists // Bioorganic and Medicinal Chemistry Letters. 2000. Vol. 10. No. 12. pp. 1377-1380.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/s0960-894x(00)00246-8
UR - https://doi.org/10.1016/s0960-894x(00)00246-8
TI - Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Pabel, Jörg
AU - Höfner, Georg
AU - Wanner, K. T.
PY - 2000
DA - 2000/06/01
PB - Elsevier
SP - 1377-1380
IS - 12
VL - 10
PMID - 10890168
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2000_Pabel,
author = {Jörg Pabel and Georg Höfner and K. T. Wanner},
title = {Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2000},
volume = {10},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/s0960-894x(00)00246-8},
number = {12},
pages = {1377--1380},
doi = {10.1016/s0960-894x(00)00246-8}
}
Cite this
MLA
Copy
Pabel, Jörg, et al. “Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists.” Bioorganic and Medicinal Chemistry Letters, vol. 10, no. 12, Jun. 2000, pp. 1377-1380. https://doi.org/10.1016/s0960-894x(00)00246-8.