Synthesis and resolution of 7-fluorotryptophans
1
Departments of Chemistry and Biochemistry, School of Chemical Sciences, University of Georgia, Athens, GA 30602 Greece
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Publication type: Journal Article
Publication date: 1991-01-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
7-Fluoro-DL-tryptophan (1a), 4,7-difluoro-DL-tryptophan (1b) and 5,7-difluoro-DL-tryptophan (1c) were prepared by Fischer indole cyclization. The resolution was achieved by treatment of the N-trifluoroacetly derivatices with carboxypeptidase A. All 7-fluorotryptophans are slow substrates for tryptophan indole-lyase from E. coli.
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11
Total citations:
11
Citations from 2024:
1
(9.09%)
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MLA
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GOST
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Lee M., Phillips R. L. Synthesis and resolution of 7-fluorotryptophans // Bioorganic and Medicinal Chemistry Letters. 1991. Vol. 1. No. 9. pp. 477-480.
GOST all authors (up to 50)
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Lee M., Phillips R. L. Synthesis and resolution of 7-fluorotryptophans // Bioorganic and Medicinal Chemistry Letters. 1991. Vol. 1. No. 9. pp. 477-480.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/s0960-894x(01)81109-4
UR - https://doi.org/10.1016/s0960-894x(01)81109-4
TI - Synthesis and resolution of 7-fluorotryptophans
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Lee, Minsu
AU - Phillips, Robert L.
PY - 1991
DA - 1991/01/01
PB - Elsevier
SP - 477-480
IS - 9
VL - 1
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1991_Lee,
author = {Minsu Lee and Robert L. Phillips},
title = {Synthesis and resolution of 7-fluorotryptophans},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {1991},
volume = {1},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/s0960-894x(01)81109-4},
number = {9},
pages = {477--480},
doi = {10.1016/s0960-894x(01)81109-4}
}
Cite this
MLA
Copy
Lee, Minsu, and Robert L. Phillips. “Synthesis and resolution of 7-fluorotryptophans.” Bioorganic and Medicinal Chemistry Letters, vol. 1, no. 9, Jan. 1991, pp. 477-480. https://doi.org/10.1016/s0960-894x(01)81109-4.