Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative
Yoshiki YOSHIDA
1
,
Keiji Matsuda
2
,
Hiroshi Sasaki
2
,
Yoshimi Matsumoto
3
,
Satoru Matsumoto
3
,
Hisashi Takasugi
2
1
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
|
2
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6 Kashima, Yodogawa-ku, Osaka 532-8514, Japan
|
3
Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,2-1-6 Kashima, Yodogawa-ku, Osaka 532-8514, Japan
|
Publication type: Journal Article
Publication date: 1999-11-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
10560737
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
The synthesis and anti-Helicobacter pylori activity of a novel cephem derivative FR182024 (1) are described. FR182024 having a (5-methyl-1,3,4-thiadiazol-2-yl)-thio moiety at the 3-position and a phenylacetamido at the 7-position was found to have extremely potent in vitro anti-H.pylori activity, superior therapeutic efficacy to AMPC and CAM, and low potential for causing diarrhea.
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YOSHIDA Y. et al. Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative // Bioorganic and Medicinal Chemistry Letters. 1999. Vol. 9. No. 21. pp. 3123-3126.
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YOSHIDA Y., Matsuda K., Sasaki H., Matsumoto Y., Matsumoto S., Takasugi H. Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative // Bioorganic and Medicinal Chemistry Letters. 1999. Vol. 9. No. 21. pp. 3123-3126.
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RIS
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TY - JOUR
DO - 10.1016/s0960-894x(99)00549-1
UR - https://doi.org/10.1016/s0960-894x(99)00549-1
TI - Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative
T2 - Bioorganic and Medicinal Chemistry Letters
AU - YOSHIDA, Yoshiki
AU - Matsuda, Keiji
AU - Sasaki, Hiroshi
AU - Matsumoto, Yoshimi
AU - Matsumoto, Satoru
AU - Takasugi, Hisashi
PY - 1999
DA - 1999/11/01
PB - Elsevier
SP - 3123-3126
IS - 21
VL - 9
PMID - 10560737
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (up to 50 authors)
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@article{1999_YOSHIDA,
author = {Yoshiki YOSHIDA and Keiji Matsuda and Hiroshi Sasaki and Yoshimi Matsumoto and Satoru Matsumoto and Hisashi Takasugi},
title = {Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {1999},
volume = {9},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/s0960-894x(99)00549-1},
number = {21},
pages = {3123--3126},
doi = {10.1016/s0960-894x(99)00549-1}
}
Cite this
MLA
Copy
YOSHIDA, Yoshiki, et al. “Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative.” Bioorganic and Medicinal Chemistry Letters, vol. 9, no. 21, Nov. 1999, pp. 3123-3126. https://doi.org/10.1016/s0960-894x(99)00549-1.