том 28 издание 6 страницы 595-602

Endothelin- and sarafotoxin-induced receptor-mediated calcium mobilization in a clonal murine osteoblast-like cell line, MC3T3-E1/B

Тип публикацииJournal Article
Дата публикации2001-06-01
scimago Q1
wos Q2
БС1
SJR1.250
CiteScore8.2
Impact factor3.6
ISSN87563282, 18732763
Histology
Physiology
Endocrinology, Diabetes and Metabolism
Краткое описание
Previous studies have demonstrated that, in osteoblast-like MC3T3-E1 cells, various endothelin peptides and their homologous sarafotoxins generate prostaglandin E(2) (PGE(2)) release through an ET(A) receptor subtype. In this study, biphasic Ca(2+) signals elicited with endothelin (ET)-1, ET-2, ET-3, beta-ET, S6a1, and S6b (ET/S6) were measured by microspectrofluorimetric methods in cell suspensions loaded with Fura-2 acetoxymethylester (Fura-2 AM). Phospholipase C (PLC)-dependent calcium activation mechanisms seem to be involved. We found evidence of Ca(2+) release from thapsigargin-sensitive and non-thapsigargin-sensitive intracellular Ca(2+) stores as well as Ca(2+) transmembrane inflow through multiple voltage-independent and Ni(2+)-sensitive cation channels. Using an ET(A) receptor antagonist, BQ-123, we showed that this receptor was coupled to Ca(2+) mobilization. All agonists tested, except S6c (an ET(B)-receptor-specific agonist) induced receptor desensitization. Our results demonstrate that the ET/S6-induced Ca(2+) signaling pathway is mediated via an ET(A)-receptor subtype in MC3T3-E1/B cells.
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Journal of Biological Chemistry
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ГОСТ |
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Zach D., Windischhofer W., Leis H. Endothelin- and sarafotoxin-induced receptor-mediated calcium mobilization in a clonal murine osteoblast-like cell line, MC3T3-E1/B // Bone. 2001. Vol. 28. No. 6. pp. 595-602.
ГОСТ со всеми авторами (до 50) Скопировать
Zach D., Windischhofer W., Leis H. Endothelin- and sarafotoxin-induced receptor-mediated calcium mobilization in a clonal murine osteoblast-like cell line, MC3T3-E1/B // Bone. 2001. Vol. 28. No. 6. pp. 595-602.
RIS |
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TY - JOUR
DO - 10.1016/s8756-3282(01)00461-6
UR - https://doi.org/10.1016/s8756-3282(01)00461-6
TI - Endothelin- and sarafotoxin-induced receptor-mediated calcium mobilization in a clonal murine osteoblast-like cell line, MC3T3-E1/B
T2 - Bone
AU - Zach, D
AU - Windischhofer, W.
AU - Leis, H.J
PY - 2001
DA - 2001/06/01
PB - Elsevier
SP - 595-602
IS - 6
VL - 28
PMID - 11425647
SN - 8756-3282
SN - 1873-2763
ER -
BibTex |
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@article{2001_Zach,
author = {D Zach and W. Windischhofer and H.J Leis},
title = {Endothelin- and sarafotoxin-induced receptor-mediated calcium mobilization in a clonal murine osteoblast-like cell line, MC3T3-E1/B},
journal = {Bone},
year = {2001},
volume = {28},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/s8756-3282(01)00461-6},
number = {6},
pages = {595--602},
doi = {10.1016/s8756-3282(01)00461-6}
}
MLA
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Zach, D., et al. “Endothelin- and sarafotoxin-induced receptor-mediated calcium mobilization in a clonal murine osteoblast-like cell line, MC3T3-E1/B.” Bone, vol. 28, no. 6, Jun. 2001, pp. 595-602. https://doi.org/10.1016/s8756-3282(01)00461-6.