Effect of lipids and proteins on the viscosity of gastric mucus glycoprotein
Publication type: Journal Article
Publication date: 1984-06-01
scimago Q2
wos Q3
SJR: 0.748
CiteScore: 4.9
Impact factor: 2.2
ISSN: 0006291X, 10902104
PubMed ID:
6732822
Biochemistry
Molecular Biology
Cell Biology
Biophysics
Abstract
The effect of associated lipids and covalently bound fatty acids, and the contribution of serum albumin and secretory IgA to the viscosity of dog gastric mucus glycoprotein was investigated. Using a cone/plate viscometer at shear rates between 1.15 – 230s −1 , it was found that extraction of associated lipids from the glycoprotein lead to 80–85% decrease in the viscosity. Further loss (39%) in viscosity of the delipidated glycoprotein occurred following removal of covalently bound fatty acids. Reassociation of the delipidated glycoprotein with its neutral lipids increased the viscosity 3-fold, a 2.5-fold increase was obtained with glycolipids, and 2-fold with phospholipids. Preincubation of purified mucus glycoprotein with albumin or IgA resulted in the increase in viscosity. This increase in viscosity was proportional to albumin concentration up to 10%, and to IgA concentration up to 5%. The results show that interaction of lipids and proteins with mucus glycoprotein contributes significantly to the viscosity of gastric mucus.
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103
Total citations:
103
Citations from 2024:
1
(0.97%)
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MLA
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GOST
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Murty V. et al. Effect of lipids and proteins on the viscosity of gastric mucus glycoprotein // Biochemical and Biophysical Research Communications. 1984. Vol. 121. No. 2. pp. 521-529.
GOST all authors (up to 50)
Copy
Murty V., Sarosiek J., Slomiany A., Slomiany B. L. Effect of lipids and proteins on the viscosity of gastric mucus glycoprotein // Biochemical and Biophysical Research Communications. 1984. Vol. 121. No. 2. pp. 521-529.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/0006-291x(84)90213-4
UR - https://doi.org/10.1016/0006-291x(84)90213-4
TI - Effect of lipids and proteins on the viscosity of gastric mucus glycoprotein
T2 - Biochemical and Biophysical Research Communications
AU - Murty, V.L.N.
AU - Sarosiek, J.
AU - Slomiany, A.
AU - Slomiany, B. L.
PY - 1984
DA - 1984/06/01
PB - Elsevier
SP - 521-529
IS - 2
VL - 121
PMID - 6732822
SN - 0006-291X
SN - 1090-2104
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1984_Murty,
author = {V.L.N. Murty and J. Sarosiek and A. Slomiany and B. L. Slomiany},
title = {Effect of lipids and proteins on the viscosity of gastric mucus glycoprotein},
journal = {Biochemical and Biophysical Research Communications},
year = {1984},
volume = {121},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/0006-291x(84)90213-4},
number = {2},
pages = {521--529},
doi = {10.1016/0006-291x(84)90213-4}
}
Cite this
MLA
Copy
Murty, V.L.N., et al. “Effect of lipids and proteins on the viscosity of gastric mucus glycoprotein.” Biochemical and Biophysical Research Communications, vol. 121, no. 2, Jun. 1984, pp. 521-529. https://doi.org/10.1016/0006-291x(84)90213-4.