Open Access
The hepatic microsomal metabolism of β-3,4-methylenedioxyamphetamine (MDA)
Тип публикации: Journal Article
Дата публикации: 1974-11-01
scimago Q1
wos Q1
БС1
SJR: 1.315
CiteScore: 10.9
Impact factor: 5.1
ISSN: 00243205, 18790631
PubMed ID:
4157281
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Pharmacology, Toxicology and Pharmaceutics
Краткое описание
Rat liver microsomes were shown to catalyze the conversion of MDA to a metabolite identified as α-MeDA. Characterization of this enzyme system strongly suggests that this conversion is catalyzed by the microsomal NADPH-dependent cytochrome P-450 hydroxylase known to catalyze the demethylenation of other methylenedioxyphenyl compounds. The relative constancy of the sum of MDA and α-MeDA, observed throughout all incubations, suggests that MDA is metabolized to only α-MeDA and that α-MeDA is not further metabolized under these conditions. A kinetic analysis of the microsomal metabolism of MDA to α-MeDA suggests the involvement of only one homogeneous enzyme system.
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ГОСТ
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Marquardt G. M., DISTEFANO V. The hepatic microsomal metabolism of β-3,4-methylenedioxyamphetamine (MDA) // Life Sciences. 1974. Vol. 15. No. 9. pp. 1603-1610.
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Marquardt G. M., DISTEFANO V. The hepatic microsomal metabolism of β-3,4-methylenedioxyamphetamine (MDA) // Life Sciences. 1974. Vol. 15. No. 9. pp. 1603-1610.
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TY - JOUR
DO - 10.1016/0024-3205(74)90326-9
UR - https://doi.org/10.1016/0024-3205(74)90326-9
TI - The hepatic microsomal metabolism of β-3,4-methylenedioxyamphetamine (MDA)
T2 - Life Sciences
AU - Marquardt, Gerald M
AU - DISTEFANO, VICTOR
PY - 1974
DA - 1974/11/01
PB - Elsevier
SP - 1603-1610
IS - 9
VL - 15
PMID - 4157281
SN - 0024-3205
SN - 1879-0631
ER -
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@article{1974_Marquardt,
author = {Gerald M Marquardt and VICTOR DISTEFANO},
title = {The hepatic microsomal metabolism of β-3,4-methylenedioxyamphetamine (MDA)},
journal = {Life Sciences},
year = {1974},
volume = {15},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/0024-3205(74)90326-9},
number = {9},
pages = {1603--1610},
doi = {10.1016/0024-3205(74)90326-9}
}
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MLA
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Marquardt, Gerald M., and VICTOR DISTEFANO. “The hepatic microsomal metabolism of β-3,4-methylenedioxyamphetamine (MDA).” Life Sciences, vol. 15, no. 9, Nov. 1974, pp. 1603-1610. https://doi.org/10.1016/0024-3205(74)90326-9.