Isolation of a new lipoxygenase metabolite of arachidonic acid, 8,11,12-trihydroxy-5,9,14-eicosatrienoic acid from human platelets
Тип публикации: Journal Article
Дата публикации: 1979-01-01
PubMed ID:
108769
Biochemistry
Endocrinology
Краткое описание
Washed human platelets incubated with 1-14C-arachidonic acid (1mM) produced a new metabolite which migrated on thin layer chromatography close to thromboxane B2, but which was identified by mass spectrometry as a trihydroxy fatty acid. The mass spectrum was consistent with the assigned structure, 8,11,12-trihydroxy-5,9,14-eicosatrienoic acid (THETE). Platelet THETE synthesis from arachidonate was not inhibited by preincubation with asprin or indomethacin but was blocked by 5,8,11,14-eicosatetraynoic acid. Therefore, THETE appears to arise via the platelet lipoxygenase pathway rather than via the prostaglandin cyclooxygenase. Two proposed structures, including a novel dihydro-hydroxy-pyran cyclic intermediate, which could give rise to THETE are presented.
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Bryant R. W., Bailey J. M. Isolation of a new lipoxygenase metabolite of arachidonic acid, 8,11,12-trihydroxy-5,9,14-eicosatrienoic acid from human platelets // Prostaglandins. 1979. Vol. 17. No. 1. pp. 9-18.
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Bryant R. W., Bailey J. M. Isolation of a new lipoxygenase metabolite of arachidonic acid, 8,11,12-trihydroxy-5,9,14-eicosatrienoic acid from human platelets // Prostaglandins. 1979. Vol. 17. No. 1. pp. 9-18.
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TY - JOUR
DO - 10.1016/0090-6980(79)90071-6
UR - https://doi.org/10.1016/0090-6980(79)90071-6
TI - Isolation of a new lipoxygenase metabolite of arachidonic acid, 8,11,12-trihydroxy-5,9,14-eicosatrienoic acid from human platelets
T2 - Prostaglandins
AU - Bryant, Robert W.
AU - Bailey, J. Martyn
PY - 1979
DA - 1979/01/01
PB - Elsevier
SP - 9-18
IS - 1
VL - 17
PMID - 108769
SN - 0090-6980
ER -
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@article{1979_Bryant,
author = {Robert W. Bryant and J. Martyn Bailey},
title = {Isolation of a new lipoxygenase metabolite of arachidonic acid, 8,11,12-trihydroxy-5,9,14-eicosatrienoic acid from human platelets},
journal = {Prostaglandins},
year = {1979},
volume = {17},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/0090-6980(79)90071-6},
number = {1},
pages = {9--18},
doi = {10.1016/0090-6980(79)90071-6}
}
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MLA
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Bryant, Robert W., and J. Martyn Bailey. “Isolation of a new lipoxygenase metabolite of arachidonic acid, 8,11,12-trihydroxy-5,9,14-eicosatrienoic acid from human platelets.” Prostaglandins, vol. 17, no. 1, Jan. 1979, pp. 9-18. https://doi.org/10.1016/0090-6980(79)90071-6.
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