Unsaturated fatty acids stimulate the formation of lipoxygenase and cyclooxygenase products in rat spleen lymphocytes
1
Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London W1P 7PN, England
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Publication type: Journal Article
Publication date: 1984-06-01
SJR: —
CiteScore: —
Impact factor: —
ISSN: 02621746
PubMed ID:
6431448
Biochemistry
Endocrinology
Physiology
Abstract
Rat spleen lymphocytes prelabelled with [14C] arachidonate were suspended in fresh medium in the presence or absence of exogenous non-radioactive fatty acids added in ethanol. It was found that fatty acids stimulate thromboxane B2, PGE2, HHT and HETE formation. The effect is specific for unsaturated fatty acids. It occurs at 50 micron concentrations and is apparent after 20 minutes incubation. Unsaturated fatty acids may serve an important role in the regulation of prostaglandin and hydroxy fatty acid metabolism in vivo. This may indicate a mechanism for the action of fatty acids on the immune response.
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GOST
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Homa S., Conroy D. M., Smith A. Unsaturated fatty acids stimulate the formation of lipoxygenase and cyclooxygenase products in rat spleen lymphocytes // Prostaglandins Leukotrienes and Medicine. 1984. Vol. 14. No. 3. pp. 417-427.
GOST all authors (up to 50)
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Homa S., Conroy D. M., Smith A. Unsaturated fatty acids stimulate the formation of lipoxygenase and cyclooxygenase products in rat spleen lymphocytes // Prostaglandins Leukotrienes and Medicine. 1984. Vol. 14. No. 3. pp. 417-427.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/0262-1746(84)90125-2
UR - https://doi.org/10.1016/0262-1746(84)90125-2
TI - Unsaturated fatty acids stimulate the formation of lipoxygenase and cyclooxygenase products in rat spleen lymphocytes
T2 - Prostaglandins Leukotrienes and Medicine
AU - Homa, Sheryl
AU - Conroy, Dolores M.
AU - Smith, Anthony
PY - 1984
DA - 1984/06/01
PB - Elsevier
SP - 417-427
IS - 3
VL - 14
PMID - 6431448
SN - 0262-1746
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1984_Homa,
author = {Sheryl Homa and Dolores M. Conroy and Anthony Smith},
title = {Unsaturated fatty acids stimulate the formation of lipoxygenase and cyclooxygenase products in rat spleen lymphocytes},
journal = {Prostaglandins Leukotrienes and Medicine},
year = {1984},
volume = {14},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/0262-1746(84)90125-2},
number = {3},
pages = {417--427},
doi = {10.1016/0262-1746(84)90125-2}
}
Cite this
MLA
Copy
Homa, Sheryl, et al. “Unsaturated fatty acids stimulate the formation of lipoxygenase and cyclooxygenase products in rat spleen lymphocytes.” Prostaglandins Leukotrienes and Medicine, vol. 14, no. 3, Jun. 1984, pp. 417-427. https://doi.org/10.1016/0262-1746(84)90125-2.