The effect of a prostacyclin analogue (Iloprost) on skin temperature
1
Department of Vascular Surgery and Medicine, Glasgow Royal Infirmary, Scotland
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2
Department of Pathology and Medicine, Glasgow Royal Infirmary, Scotland
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Publication type: Journal Article
Publication date: 1985-09-01
SJR: —
CiteScore: —
Impact factor: —
ISSN: 02621746
PubMed ID:
2414783
Biochemistry
Endocrinology
Physiology
Abstract
Skin temperature was measured in the forearms of 8 healthy volunteers to study the effect of transdermal application of a stable prostacyclin analogue (Iloprost). Local skin temperature was significantly increased 24 hours and 48 hours after application of the drug when compared with an area of control skin. The effect had worn off by 72 hours. At a dose of 25μg there were no systemic effects of vasodilatation or antiplatelet behaviour, but when the dose was increased to 75μg there was a decreased rate of platelet aggregation for 24 hours. Histology of a skin biopsy suggested that the increase in skin temperature was due to vasodilatation and not acute inflammatory reaction. The results of this pilot study suggest that transdermal application of Iloprost is a suitable vehicle for administration of the drug and a prospective randomised trial is proposed for patients with Raynaud's Syndrome. proposed for patients with Raynaud's Syndrome.
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Drury J. K. et al. The effect of a prostacyclin analogue (Iloprost) on skin temperature // Prostaglandins Leukotrienes and Medicine. 1985. Vol. 19. No. 3. pp. 301-303.
GOST all authors (up to 50)
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Drury J. K., McGregor M. The effect of a prostacyclin analogue (Iloprost) on skin temperature // Prostaglandins Leukotrienes and Medicine. 1985. Vol. 19. No. 3. pp. 301-303.
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RIS
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TY - JOUR
DO - 10.1016/0262-1746(85)90143-x
UR - https://doi.org/10.1016/0262-1746(85)90143-x
TI - The effect of a prostacyclin analogue (Iloprost) on skin temperature
T2 - Prostaglandins Leukotrienes and Medicine
AU - Drury, J K
AU - McGregor, M.
PY - 1985
DA - 1985/09/01
PB - Elsevier
SP - 301-303
IS - 3
VL - 19
PMID - 2414783
SN - 0262-1746
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1985_Drury,
author = {J K Drury and M. McGregor},
title = {The effect of a prostacyclin analogue (Iloprost) on skin temperature},
journal = {Prostaglandins Leukotrienes and Medicine},
year = {1985},
volume = {19},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/0262-1746(85)90143-x},
number = {3},
pages = {301--303},
doi = {10.1016/0262-1746(85)90143-x}
}
Cite this
MLA
Copy
Drury, J. K., et al. “The effect of a prostacyclin analogue (Iloprost) on skin temperature.” Prostaglandins Leukotrienes and Medicine, vol. 19, no. 3, Sep. 1985, pp. 301-303. https://doi.org/10.1016/0262-1746(85)90143-x.