Platelet hyperaggregiability in cystic fibrosis
R. J. Stead
1
,
M. A. Barradas
1
,
Dimitri P. Mikhailidis
1
,
J.Y. Jeremy
1
,
Margaret E. Hodson
2
,
J. C. Batten
1
,
Paresh Dandona
1
1
Metabolic Unit, Department of Chemical pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London NW3 2QG, UK
|
2
Department of Cystic Fibrosis, Cardiothoracic Institute and Brompton Hospital, London SQ3 6HP, UK
|
Publication type: Journal Article
Publication date: 1987-02-01
SJR: —
CiteScore: —
Impact factor: —
ISSN: 02621746
PubMed ID:
3470815
Biochemistry
Endocrinology
Physiology
Abstract
Platelet function was investigated in 15 patients with cystic fibrosis (CF) and in ten age-matched controls. Marked hyperaggregability of platelets to adrenaline, collagen and arachidonic acid was observed in platelet rich plasma (PRP) prepared from patients with cystic fibrosis. Thromboxane A2 (TXA2) release from these platelets was also markedly enhanced. Hyperaggregability and increased TXA2 release observed in patients with CF was not due to the higher platelet counts in these patients since hyperaggregability was observed even in those patients whose platelet counts were similar to those in controls. Platelet hyperaggregability and increased thromboxane release in these patients were also independent of their body weight and occurred despite supplementation with vitamin E. Hyperaggregability of platelets in CF may be clinically relevant since it may contribute to the pathogenesis of bronchoconstriction through the release of TXA2 and other bronchoconstrictor platelet products such as serotonin.
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Metrics
22
Total citations:
22
Citations from 2024:
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The most citing journal
Citations in journal:
3
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Stead R. J. et al. Platelet hyperaggregiability in cystic fibrosis // Prostaglandins Leukotrienes and Medicine. 1987. Vol. 26. No. 2. pp. 91-103.
GOST all authors (up to 50)
Copy
Stead R. J., Barradas M. A., Mikhailidis D. P., Jeremy J., Hodson M. E., Batten J. C., Dandona P. Platelet hyperaggregiability in cystic fibrosis // Prostaglandins Leukotrienes and Medicine. 1987. Vol. 26. No. 2. pp. 91-103.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/0262-1746(87)90104-1
UR - https://doi.org/10.1016/0262-1746(87)90104-1
TI - Platelet hyperaggregiability in cystic fibrosis
T2 - Prostaglandins Leukotrienes and Medicine
AU - Stead, R. J.
AU - Barradas, M. A.
AU - Mikhailidis, Dimitri P.
AU - Jeremy, J.Y.
AU - Hodson, Margaret E.
AU - Batten, J. C.
AU - Dandona, Paresh
PY - 1987
DA - 1987/02/01
PB - Elsevier
SP - 91-103
IS - 2
VL - 26
PMID - 3470815
SN - 0262-1746
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1987_Stead,
author = {R. J. Stead and M. A. Barradas and Dimitri P. Mikhailidis and J.Y. Jeremy and Margaret E. Hodson and J. C. Batten and Paresh Dandona},
title = {Platelet hyperaggregiability in cystic fibrosis},
journal = {Prostaglandins Leukotrienes and Medicine},
year = {1987},
volume = {26},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/0262-1746(87)90104-1},
number = {2},
pages = {91--103},
doi = {10.1016/0262-1746(87)90104-1}
}
Cite this
MLA
Copy
Stead, R. J., et al. “Platelet hyperaggregiability in cystic fibrosis.” Prostaglandins Leukotrienes and Medicine, vol. 26, no. 2, Feb. 1987, pp. 91-103. https://doi.org/10.1016/0262-1746(87)90104-1.