Open Access
Preparation and purification of polyisohexylcyanoacrylate nanocapsules
Publication type: Journal Article
Publication date: 1991-06-01
scimago Q1
wos Q1
SJR: 0.988
CiteScore: 10.1
Impact factor: 5.2
ISSN: 03785173, 18733476
Pharmaceutical Science
Abstract
Nanocapsules (200 nm diameter) were prepared by interfacial polymerization of isohexylcyanoacrylate in an oil-in-water emulsion. Sulphur dioxide was added to the monomer prior to its dissolution in the oil-ethanol phase in order to avoid immediate polymerization. Upon addition to the aqueous phase, interfacial polymerization occurred resulting in the formation of nanocapsules. The effect of different variables on nanocapsule size was evaluated. Miglyol concentration played a major role by controlling the size of emulsified droplets while SO 2 and pH only slightly affected nanocapsule size. Monomer concentration showed a significant effect on the density, indicating that polymeric walls of different thicknesses can be obtained. Finally, a purification method based on centrifugation and redispersion was developed.
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37
Total citations:
37
Citations from 2025:
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MLA
Cite this
GOST
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Chouinard F. et al. Preparation and purification of polyisohexylcyanoacrylate nanocapsules // International Journal of Pharmaceutics. 1991. Vol. 72. No. 3. pp. 211-217.
GOST all authors (up to 50)
Copy
Chouinard F., Kan F., Leroux J. L., Foucher C., Lenaerts V. Preparation and purification of polyisohexylcyanoacrylate nanocapsules // International Journal of Pharmaceutics. 1991. Vol. 72. No. 3. pp. 211-217.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/0378-5173(91)90110-a
UR - https://doi.org/10.1016/0378-5173(91)90110-a
TI - Preparation and purification of polyisohexylcyanoacrylate nanocapsules
T2 - International Journal of Pharmaceutics
AU - Chouinard, Francois
AU - Kan, FW
AU - Leroux, Jean Louis
AU - Foucher, Christophe
AU - Lenaerts, Vincent
PY - 1991
DA - 1991/06/01
PB - Elsevier
SP - 211-217
IS - 3
VL - 72
SN - 0378-5173
SN - 1873-3476
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1991_Chouinard,
author = {Francois Chouinard and FW Kan and Jean Louis Leroux and Christophe Foucher and Vincent Lenaerts},
title = {Preparation and purification of polyisohexylcyanoacrylate nanocapsules},
journal = {International Journal of Pharmaceutics},
year = {1991},
volume = {72},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/0378-5173(91)90110-a},
number = {3},
pages = {211--217},
doi = {10.1016/0378-5173(91)90110-a}
}
Cite this
MLA
Copy
Chouinard, Francois, et al. “Preparation and purification of polyisohexylcyanoacrylate nanocapsules.” International Journal of Pharmaceutics, vol. 72, no. 3, Jun. 1991, pp. 211-217. https://doi.org/10.1016/0378-5173(91)90110-a.