Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: a novel class of water soluble paclitaxel pro-drugs
Тип публикации: Journal Article
Дата публикации: 1996-08-01
SCImago Q2
WOS Q2
БС2
SJR: 0.426
CiteScore: 4.5
Impact factor: 2.3
ISSN: 0960894X, 14643405
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
The synthesis, pharmacokinetic properties, and antitumor evaluation of novel paclitaxel phosphonooxymethyl ether derivatives 8–11 and salts thereof is described. These compounds exhibit improved water solubility as compared to paclitaxel (1) and upon incubation with plasma and alkaline phosphatase they readily release parent drug. The in vivo antitumor evaluation of compounds 8–11 established them as suitable pro-drugs of paclitaxel.
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Метрики
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Всего цитирований:
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MLA
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ГОСТ
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Golik J. et al. Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: a novel class of water soluble paclitaxel pro-drugs // Bioorganic and Medicinal Chemistry Letters. 1996. Vol. 6. No. 15. pp. 1837-1842.
ГОСТ со всеми авторами (до 50)
Скопировать
Golik J., Wong H. N. C., Chen S., Doyle T. W., Kim Wright J. J., Knipe J. O., ROSE W. C., Casazza A., Vyas D. M. Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: a novel class of water soluble paclitaxel pro-drugs // Bioorganic and Medicinal Chemistry Letters. 1996. Vol. 6. No. 15. pp. 1837-1842.
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RIS
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TY - JOUR
DO - 10.1016/0960-894X(96)00321-6
UR - https://doi.org/10.1016/0960-894X(96)00321-6
TI - Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: a novel class of water soluble paclitaxel pro-drugs
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Golik, Jerzy
AU - Wong, Henry N. C.
AU - Chen, Shu
AU - Doyle, Terrence W.
AU - Kim Wright, J J
AU - Knipe, Jay O.
AU - ROSE, WILLIAM C.
AU - Casazza, A.P
AU - Vyas, Dolatrai M
PY - 1996
DA - 1996/08/01
PB - Elsevier
SP - 1837-1842
IS - 15
VL - 6
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (до 50 авторов)
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@article{1996_Golik,
author = {Jerzy Golik and Henry N. C. Wong and Shu Chen and Terrence W. Doyle and J J Kim Wright and Jay O. Knipe and WILLIAM C. ROSE and A.P Casazza and Dolatrai M Vyas},
title = {Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: a novel class of water soluble paclitaxel pro-drugs},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {1996},
volume = {6},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/0960-894X(96)00321-6},
number = {15},
pages = {1837--1842},
doi = {10.1016/0960-894X(96)00321-6}
}
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MLA
Скопировать
Golik, Jerzy, et al. “Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: a novel class of water soluble paclitaxel pro-drugs.” Bioorganic and Medicinal Chemistry Letters, vol. 6, no. 15, Aug. 1996, pp. 1837-1842. https://doi.org/10.1016/0960-894X(96)00321-6.
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