Bioorganic and Medicinal Chemistry

, том 4 , издание 1 , страницы 81-90

Synthesis of hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties

Тип публикации: Journal Article

Дата публикации: 1996-01-01

Elsevier

Bioorganic and Medicinal Chemistry

SCImago Q2

WOS Q1

БС1

SJR: 0.582

CiteScore: 5.6

Impact factor: 3.5

ISSN: 09680896, 14643391

DOI: 10.1016/0968-0896(95)00173-5

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PubMed ID: 8689243

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Краткое описание

The rationale for investigating conformationally restricted analogues of BW245C as DP-receptor ligands and the syntheses of three such racemic bicyclic imidazolidinone analogues are described. Compounds 7 (BW587C), 8 (BW480C85), and 9 (BW572C85) were found to be potent inhibitors of human platelet aggregation and selective DP-receptor agonists in washed platelet and jugular vein isolated tissue assays.

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Journal of Medicinal Chemistry	Journal of Medicinal Chemistry, 2, 11.11% Journal of Medicinal Chemistry 2 публикации, 11.11%
Tetrahedron Letters	Tetrahedron Letters, 2, 11.11% Tetrahedron Letters 2 публикации, 11.11%
Journal of Heterocyclic Chemistry	Journal of Heterocyclic Chemistry, 2, 11.11% Journal of Heterocyclic Chemistry 2 публикации, 11.11%
Pharmacological Reviews	Pharmacological Reviews, 1, 5.56% Pharmacological Reviews 1 публикация, 5.56%
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Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry	Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 1, 5.56% Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 1 публикация, 5.56%
Bioorganic and Medicinal Chemistry Letters	Bioorganic and Medicinal Chemistry Letters, 1, 5.56% Bioorganic and Medicinal Chemistry Letters 1 публикация, 5.56%
Tetrahedron	Tetrahedron, 1, 5.56% Tetrahedron 1 публикация, 5.56%
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Heteroatom Chemistry	Heteroatom Chemistry, 1, 5.56% Heteroatom Chemistry 1 публикация, 5.56%
Organic Preparations and Procedures International	Organic Preparations and Procedures International, 1, 5.56% Organic Preparations and Procedures International 1 публикация, 5.56%
Phosphorus, Sulfur and Silicon and the Related Elements	Phosphorus, Sulfur and Silicon and the Related Elements, 1, 5.56% Phosphorus, Sulfur and Silicon and the Related Elements 1 публикация, 5.56%
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ГОСТ |

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Barraclough P. et al. Synthesis of hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties // Bioorganic and Medicinal Chemistry. 1996. Vol. 4. No. 1. pp. 81-90.

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Barraclough P., Bolofo M. L., Giles H., Gillam J., John Harris C., Kelly M., LEFF P., McNeill A., Robertson A. D., Stepney R. J., Whittle B. J. R. Synthesis of hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties // Bioorganic and Medicinal Chemistry. 1996. Vol. 4. No. 1. pp. 81-90.

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TY - JOUR

DO - 10.1016/0968-0896(95)00173-5

UR - https://doi.org/10.1016/0968-0896(95)00173-5

TI - Synthesis of hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties

T2 - Bioorganic and Medicinal Chemistry

AU - Barraclough, Paul

AU - Bolofo, Mary L.

AU - Giles, Heather

AU - Gillam, Janet

AU - John Harris, C.

AU - Kelly, Michael

AU - LEFF, PAUL

AU - McNeill, Alan

AU - Robertson, Alan D.

AU - Stepney, Ray J

AU - Whittle, Brendan J. R.

PY - 1996

DA - 1996/01/01

PB - Elsevier

SP - 81-90

IS - 1

VL - 4

PMID - 8689243

SN - 0968-0896

SN - 1464-3391

ER -

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@article{1996_Barraclough,

author = {Paul Barraclough and Mary L. Bolofo and Heather Giles and Janet Gillam and C. John Harris and Michael Kelly and PAUL LEFF and Alan McNeill and Alan D. Robertson and Ray J Stepney and Brendan J. R. Whittle},

title = {Synthesis of hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties},

journal = {Bioorganic and Medicinal Chemistry},

year = {1996},

volume = {4},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1016/0968-0896(95)00173-5},

number = {1},

pages = {81--90},

doi = {10.1016/0968-0896(95)00173-5}

}

MLA

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MLA Скопировать

Barraclough, Paul, et al. “Synthesis of hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties.” Bioorganic and Medicinal Chemistry, vol. 4, no. 1, Jan. 1996, pp. 81-90. https://doi.org/10.1016/0968-0896(95)00173-5.

Издатель

Elsevier

Журнал

Bioorganic and Medicinal Chemistry

SCImago Q2

WOS Q1

БС1

SJR

0.582

CiteScore

5.6

Impact factor