Identification and characterization of a new member of the TNF family that induces apoptosis
Steven R. Wiley
1
,
Ken Schooley
1
,
Pamela J Smolak
1
,
Wenie S Din
1
,
Chang-Pin Huang
1
,
Jillian K Nicholl
2
,
GRANT R. SUTHERLAND
2
,
Terri Davis Smith
1
,
Charles Rauch
1
,
Craig V. Smith
1
,
Raymond G. Goodwin
1
1
Immunex Research and Development Corporation 51 University Street Seattle, Washington 98101, USA
|
Publication type: Journal Article
Publication date: 1995-12-01
scimago Q1
wos Q1
SJR: 12.163
CiteScore: 40.8
Impact factor: 26.3
ISSN: 10747613, 10974180
PubMed ID:
8777713
Infectious Diseases
Immunology
Immunology and Allergy
Abstract
A novel tumor necrosis factor (TNF) family member has been cloned and characterized. This protein, designated TNF-related apoptosis-inducing ligand (TRAIL), consists of 281 and 291 aa in the human and murine forms, respectively, which share 65% aa identity. TRAIL is a type II membrane protein, whose C-terminal extracellular domain shows clear homology to other TNF family members. TRAIL transcripts are detected in a variety of human tissues, most predominantly in spleen, lung, and prostate. The TRAIL gene is located on chromosome 3 at position 3q26, which is not close to any other known TNF ligand family members. Both full-length cell surface expressed TRAIL and picomolar concentrations of soluble TRAIL rapidly induce apoptosis in a wide variety of transformed cell lines of diverse origin.
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GOST
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Wiley S. R. et al. Identification and characterization of a new member of the TNF family that induces apoptosis // Immunity. 1995. Vol. 3. No. 6. pp. 673-682.
GOST all authors (up to 50)
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Wiley S. R., Schooley K., Smolak P. J., Din W. S., Huang C., Nicholl J. K., SUTHERLAND G. R., Smith T. D., Rauch C., Smith C. V., Goodwin R. G. Identification and characterization of a new member of the TNF family that induces apoptosis // Immunity. 1995. Vol. 3. No. 6. pp. 673-682.
Cite this
RIS
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TY - JOUR
DO - 10.1016/1074-7613(95)90057-8
UR - https://doi.org/10.1016/1074-7613(95)90057-8
TI - Identification and characterization of a new member of the TNF family that induces apoptosis
T2 - Immunity
AU - Wiley, Steven R.
AU - Schooley, Ken
AU - Smolak, Pamela J
AU - Din, Wenie S
AU - Huang, Chang-Pin
AU - Nicholl, Jillian K
AU - SUTHERLAND, GRANT R.
AU - Smith, Terri Davis
AU - Rauch, Charles
AU - Smith, Craig V.
AU - Goodwin, Raymond G.
PY - 1995
DA - 1995/12/01
PB - Elsevier
SP - 673-682
IS - 6
VL - 3
PMID - 8777713
SN - 1074-7613
SN - 1097-4180
ER -
Cite this
BibTex (up to 50 authors)
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@article{1995_Wiley,
author = {Steven R. Wiley and Ken Schooley and Pamela J Smolak and Wenie S Din and Chang-Pin Huang and Jillian K Nicholl and GRANT R. SUTHERLAND and Terri Davis Smith and Charles Rauch and Craig V. Smith and Raymond G. Goodwin},
title = {Identification and characterization of a new member of the TNF family that induces apoptosis},
journal = {Immunity},
year = {1995},
volume = {3},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/1074-7613(95)90057-8},
number = {6},
pages = {673--682},
doi = {10.1016/1074-7613(95)90057-8}
}
Cite this
MLA
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Wiley, Steven R., et al. “Identification and characterization of a new member of the TNF family that induces apoptosis.” Immunity, vol. 3, no. 6, Dec. 1995, pp. 673-682. https://doi.org/10.1016/1074-7613(95)90057-8.