Flavone

Flavone scaffolds comprehensively discovered heterocyclic ring systems for numerous pathological conditions with antioxidant, antiproliferative, antitumor, and antimicrobial properties. The scaffold has been widely used for multitargeting in complex diseases like cancer, inflammation, cardiovascular disease, diabetes, and various neurodegenerative disorders. Due to the wide range of biological activities of flavones, their structure–activity relationships have generated interest among medicinal chemists. The outstanding development of flavone derivatives in diverse diseases in a very short span of time proves its magnitude for medicinal chemistry research. This chapter details structural requirements of flavone derivatives for various pharmacological activities. This information may provide an opportunity to medicinal chemistry scientists to design selective, optimized, and polyfunctional flavone derivatives for the treatment of multifactorial diseases.