pages 618-620

Tetrabenazine

Thomas F Derosa
Publication typeBook Chapter
Publication date2006-01-01
Abstract
This chapter of the book Advances in Synthetic Organic Chemistry discusses tetrabenazine in detail. It mentions one US patent in complete detail. The patent is described in a format that is followed throughout the book. The patent covered in this chapter is iodine derivatives of tetrabenazine, authored by H.F. Kung. The chapter mentions other details about the patent before discussing the organic compound. These details include the assignee and the utility designation. The assignee for this patent is the Trustees of The University of Pennsylvania and the utility designation is preparation of monoamine uptake inhibitors and radiolabeled derivatives. Thereafter, the chapter describes reactions related to tetrabenazine. This is followed by experimental details. It also outlines some useful notes for further explanation. Lastly, certain references to other significant prior US patents are mentioned.
Wetlands scimago Q2 wos Q3
1994-12-01 citations by CoLab: 9
Antonova Alexandra S., Zubkov Fedor I.
Russian Chemical Reviews scimago Q1 wos Q1 Open Access
2024-08-30 citations by CoLab: 1 PDF Abstract  
Catalytic olefin metathesis using Hoveyda-Grubbs type ruthenium complexes is a powerful tool for creating complex molecules possessing a variety of practically useful properties. This method is also applied for obtaining modern polymer materials from low-demand petroleum products. Among all ruthenium complexes containing five- or six-membered chelate rings, the commercially available HG-II catalyst is the most common. In addition, other Hoveyda-Grubbs type complexes, which include a Het→Ru donor–acceptor bond in the chelate ring, often exhibit metathesis activity equal to or superior to that of HG-II. This review considers second-generation N-heterocyclic ruthenium carbene Hoveyda-Grubbs type complexes with donor–acceptor bonds such as O→Ru, S→Ru, Se→Ru, N→Ru, P→Ru and Hal→Ru in the chelate ring. Methods of preparation, analysis of stability and catalytic activity of such complexes are compared, and examples of the application of these organometallic ruthenium derivatives in the synthesis of practically relevant products are provided. The literature from 2010 to 2023 is summarized, making this review useful for a broad audience of chemists working in heterocyclic and organometallic chemistry, as well as practitioners involved in the production of catalysts and polymers.The bibliography includes 174 references.

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