Cell, volume 181, issue 5, pages 1004-1015.e15

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

Daniel Wrapp ¹

Dorien De Vlieger ²

Kizzmekia S. Corbett ³

Gretel M Torres ⁴

Nianshuang Wang ¹

Wander Van Breedam ²

K. Roose ²

Loes Van Schie ²

Markus Hoffmann ⁵

Stefan Pöhlmann ⁶

B. Graham ³

Nico Callewaert ²

B. Schepens ²

Xavier Saelens ²

Jason S. McLellan ¹

Hide authors affiliations Show authors affiliations: 6 affiliations

Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA. |

VIB-UGent Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium |

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. |

⁴

Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA. |

⁵

Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research, 37077 Göttingen, Germany |

⁶

Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany. |

Publication type: Journal Article

Publication date: 2020-05-05

Elsevier

Journal: Cell

Quartile SCImago

Quartile WOS

Impact factor: 64.5

ISSN: 00928674, 10974172

DOI: 10.1016/j.cell.2020.04.031

Copy DOI

PubMed ID: 32375025

General Biochemistry, Genetics and Molecular Biology

Abstract

Summary

Coronaviruses make use of a large envelope protein called spike (S) to engage host cell receptors and catalyze membrane fusion. Because of the vital role that these S proteins play, they represent a vulnerable target for the development of therapeutics. Here, we describe the isolation of single-domain antibodies (VHHs) from a llama immunized with prefusion-stabilized coronavirus spikes. These VHHs neutralize MERS-CoV or SARS-CoV-1 S pseudotyped viruses, respectively. Crystal structures of these VHHs bound to their respective viral targets reveal two distinct epitopes, but both VHHs interfere with receptor binding. We also show cross-reactivity between the SARS-CoV-1 S-directed VHH and SARS-CoV-2 S and demonstrate that this cross-reactive VHH neutralizes SARS-CoV-2 S pseudotyped viruses as a bivalent human IgG Fc-fusion. These data provide a molecular basis for the neutralization of pathogenic betacoronaviruses by VHHs and suggest that these molecules may serve as useful therapeutics during coronavirus outbreaks.

By date By citations

Top-30

Citations by journals

	2 4 6 8 10 12 14 16
Scientific Reports	Scientific Reports, 16, 3.46% Scientific Reports 16 publications, 3.46%
Nature Communications	Nature Communications, 12, 2.59% Nature Communications 12 publications, 2.59%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 11, 2.38% Proceedings of the National Academy of Sciences of the United States of America 11 publications, 2.38%
Frontiers in Immunology	Frontiers in Immunology, 9, 1.94% Frontiers in Immunology 9 publications, 1.94%
Cell Reports	Cell Reports, 8, 1.73% Cell Reports 8 publications, 1.73%
Viruses	Viruses, 6, 1.3% Viruses 6 publications, 1.3%
PLoS Pathogens	PLoS Pathogens, 6, 1.3% PLoS Pathogens 6 publications, 1.3%
Cell	Cell, 6, 1.3% Cell 6 publications, 1.3%
Science	Science, 5, 1.08% Science 5 publications, 1.08%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 5, 1.08% International Journal of Molecular Sciences 5 publications, 1.08%
iScience	iScience, 5, 1.08% iScience 5 publications, 1.08%
Cells	Cells, 4, 0.86% Cells 4 publications, 0.86%
Signal Transduction and Targeted Therapy	Signal Transduction and Targeted Therapy, 4, 0.86% Signal Transduction and Targeted Therapy 4 publications, 0.86%
Communications Biology	Communications Biology, 4, 0.86% Communications Biology 4 publications, 0.86%
Journal of Biological Chemistry	Journal of Biological Chemistry, 4, 0.86% Journal of Biological Chemistry 4 publications, 0.86%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 4, 0.86% International Journal of Biological Macromolecules 4 publications, 0.86%
Advanced Science	Advanced Science, 4, 0.86% Advanced Science 4 publications, 0.86%
mAbs	mAbs, 4, 0.86% mAbs 4 publications, 0.86%
Science advances	Science advances, 4, 0.86% Science advances 4 publications, 0.86%
Journal of Medical Virology	Journal of Medical Virology, 3, 0.65% Journal of Medical Virology 3 publications, 0.65%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 3, 0.65% Frontiers in Molecular Biosciences 3 publications, 0.65%
International Immunopharmacology	International Immunopharmacology, 3, 0.65% International Immunopharmacology 3 publications, 0.65%
Computational and Structural Biotechnology Journal	Computational and Structural Biotechnology Journal, 3, 0.65% Computational and Structural Biotechnology Journal 3 publications, 0.65%
Immunity	Immunity, 3, 0.65% Immunity 3 publications, 0.65%
Biochemical and Biophysical Research Communications	Biochemical and Biophysical Research Communications, 3, 0.65% Biochemical and Biophysical Research Communications 3 publications, 0.65%
Advances in Immunology	Advances in Immunology, 2, 0.43% Advances in Immunology 2 publications, 0.43%
International Journal of Nanomedicine	International Journal of Nanomedicine, 2, 0.43% International Journal of Nanomedicine 2 publications, 0.43%
Biosensors	Biosensors, 2, 0.43% Biosensors 2 publications, 0.43%
Journal of Nanobiotechnology	Journal of Nanobiotechnology, 2, 0.43% Journal of Nanobiotechnology 2 publications, 0.43%
	2 4 6 8 10 12 14 16

Citations by publishers

	10 20 30 40 50 60 70 80 90 100
Elsevier	Elsevier, 97, 20.95% Elsevier 97 publications, 20.95%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 89, 19.22% Cold Spring Harbor Laboratory 89 publications, 19.22%
Springer Nature	Springer Nature, 68, 14.69% Springer Nature 68 publications, 14.69%
Wiley	Wiley, 35, 7.56% Wiley 35 publications, 7.56%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 29, 6.26% Multidisciplinary Digital Publishing Institute (MDPI) 29 publications, 6.26%
American Chemical Society (ACS)	American Chemical Society (ACS), 18, 3.89% American Chemical Society (ACS) 18 publications, 3.89%
Frontiers Media S.A.	Frontiers Media S.A., 17, 3.67% Frontiers Media S.A. 17 publications, 3.67%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 12, 2.59% American Association for the Advancement of Science (AAAS) 12 publications, 2.59%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 11, 2.38% Proceedings of the National Academy of Sciences (PNAS) 11 publications, 2.38%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 9, 1.94% Public Library of Science (PLoS) 9 publications, 1.94%
American Society for Microbiology	American Society for Microbiology, 9, 1.94% American Society for Microbiology 9 publications, 1.94%
Taylor & Francis	Taylor & Francis, 8, 1.73% Taylor & Francis 8 publications, 1.73%
Oxford University Press	Oxford University Press, 6, 1.3% Oxford University Press 6 publications, 1.3%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 4, 0.86% American Society for Biochemistry and Molecular Biology 4 publications, 0.86%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 4, 0.86% Royal Society of Chemistry (RSC) 4 publications, 0.86%
Bentham Science	Bentham Science, 4, 0.86% Bentham Science 4 publications, 0.86%
EMBO press	EMBO press, 3, 0.65% EMBO press 3 publications, 0.65%
Annual Reviews	Annual Reviews, 3, 0.65% Annual Reviews 3 publications, 0.65%
Mary Ann Liebert	Mary Ann Liebert, 2, 0.43% Mary Ann Liebert 2 publications, 0.43%
Dove Medical Press	Dove Medical Press, 2, 0.43% Dove Medical Press 2 publications, 0.43%
SAGE	SAGE, 2, 0.43% SAGE 2 publications, 0.43%
KeAi Communications Co.	KeAi Communications Co., 2, 0.43% KeAi Communications Co. 2 publications, 0.43%
The Royal Society	The Royal Society, 2, 0.43% The Royal Society 2 publications, 0.43%
The American Association of Immunologists	The American Association of Immunologists, 1, 0.22% The American Association of Immunologists 1 publication, 0.22%
American Society for Clinical Investigation	American Society for Clinical Investigation, 1, 0.22% American Society for Clinical Investigation 1 publication, 0.22%
Microbiology Society	Microbiology Society, 1, 0.22% Microbiology Society 1 publication, 0.22%
NEJM Group	NEJM Group, 1, 0.22% NEJM Group 1 publication, 0.22%
Portland Press	Portland Press, 1, 0.22% Portland Press 1 publication, 0.22%
Baishideng Publishing Group	Baishideng Publishing Group, 1, 0.22% Baishideng Publishing Group 1 publication, 0.22%
	10 20 30 40 50 60 70 80 90 100

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[0,0,0,0,0],"codes":[0,0,0,0,0],"imageUrls":["","","","",""],"datasets":[{"label":"Citations number","data":[98,188,88,54,35],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["21.17","40.6","19.01","11.66","7.56"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Scientific Reports","Nature Communications","Proceedings of the National Academy of Sciences of the United States of America","Frontiers in Immunology","Cell Reports","Viruses","PLoS Pathogens","Cell","Science","International Journal of Molecular Sciences","iScience","Cells","Signal Transduction and Targeted Therapy","Communications Biology","Journal of Biological Chemistry","International Journal of Biological Macromolecules","Advanced Science","mAbs","Science advances","Journal of Medical Virology","Frontiers in Molecular Biosciences","International Immunopharmacology","Computational and Structural Biotechnology Journal","Immunity","Biochemical and Biophysical Research Communications","Advances in Immunology","International Journal of Nanomedicine","Biosensors","Journal of Nanobiotechnology"],"ids":[13767,3231,306,1699,9130,2455,5093,16552,7711,14627,6073,25293,10186,11778,19451,23035,4130,9244,23003,22523,3133,11569,4268,15890,12390,13708,10956,5233,11794],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/s10mcsCV4OAUg9O2KrqOquQC0PhyLMI8hUUkuflM_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/s10mcsCV4OAUg9O2KrqOquQC0PhyLMI8hUUkuflM_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp"],"datasets":[{"label":"","data":[16,12,11,9,8,6,6,6,5,5,5,4,4,4,4,4,4,4,4,3,3,3,3,3,3,2,2,2,2],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[3.46,2.59,2.38,1.94,1.73,1.3,1.3,1.3,1.08,1.08,1.08,0.86,0.86,0.86,0.86,0.86,0.86,0.86,0.86,0.65,0.65,0.65,0.65,0.65,0.65,0.43,0.43,0.43,0.43],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Cold Spring Harbor Laboratory","Springer Nature","Wiley","Multidisciplinary Digital Publishing Institute (MDPI)","American Chemical Society (ACS)","Frontiers Media S.A.","American Association for the Advancement of Science (AAAS)","Proceedings of the National Academy of Sciences (PNAS)","Public Library of Science (PLoS)","American Society for Microbiology","Taylor & Francis","Oxford University Press","American Society for Biochemistry and Molecular Biology","Royal Society of Chemistry (RSC)","Bentham Science","EMBO press","Annual Reviews","Mary Ann Liebert","Dove Medical Press","SAGE","KeAi Communications Co.","The Royal Society","The American Association of Immunologists","American Society for Clinical Investigation","Microbiology Society","NEJM Group","Portland Press","Baishideng Publishing Group"],"ids":[17,6909,8,11,202,40,208,189,162,344,142,18,19,2090,123,39,9415,6941,230,417,31,326,259,7871,564,827,2929,801,7719],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/s10mcsCV4OAUg9O2KrqOquQC0PhyLMI8hUUkuflM_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/1UiI5HycPsvulDeXOySNp0OuaMMmIKfPnsdKPyH0_medium.webp","\/storage\/images\/resized\/A7oGMwx1m3fFJlKJvQUVra8h0itmEa7JZW0q3Q0b_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp","\/storage\/images\/resized\/ruydfaB80LDjlkYqsfOeUAZohOIODyq7bQzis5O7_medium.webp","\/storage\/images\/resized\/jeWDR7NTA9Ab5MVz8Uqjl2RPCndzFjSyl0FaRAHg_medium.webp","\/storage\/images\/resized\/BHBStD1OkQqtKFRRjS5njgNe7bXCAEgaDQVK7GTA_medium.webp","\/storage\/images\/resized\/Teo7jjEEA71rw8mjlFC8lDbYotZhhtZbL0J9gPs2_medium.webp","\/storage\/images\/resized\/aFa86lAy63Pq5tYKiOsH017UsgJA6uk6ed66C0Ns_medium.webp","\/storage\/images\/resized\/RlMKyKHh4Q2iTSKF38VHwIFW4f6Ke5ChRSXbQHkq_medium.webp","\/storage\/images\/resized\/zERSCvSmqNPcErreyd1xoLNnZOn7FU7lakrxwchY_medium.webp","\/storage\/images\/resized\/nUqNrP9GnM1t0BrAIXp1LBodjU8aIJ2Fk4pLfGhZ_medium.webp","\/storage\/images\/resized\/bKOjgSt9mSGUD9fzKZyqcKSIgDCDSMd1ZWjJOZzx_medium.webp"],"datasets":[{"label":"","data":[97,89,68,35,29,18,17,12,11,9,9,8,6,4,4,4,3,3,2,2,2,2,2,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[20.95,19.22,14.69,7.56,6.26,3.89,3.67,2.59,2.38,1.94,1.94,1.73,1.3,0.86,0.86,0.86,0.65,0.65,0.43,0.43,0.43,0.43,0.43,0.22,0.22,0.22,0.22,0.22,0.22],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,1,0,0,0],"percentage":["0","0.22","0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,4,3,3,2],"percentage":["0","0.86","0.65","0.65","0.43"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[6,11,6,9,3],"percentage":["1.3","2.38","1.3","1.94","0.65"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[53,130,61,33,24],"percentage":["11.45","28.08","13.17","7.13","5.18"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[39,42,18,9,6],"percentage":["8.42","9.07","3.89","1.94","1.3"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,2,3,1,1],"percentage":["0","0.43","0.65","0.22","0.22"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[3,10,2,1,1],"percentage":["0.65","2.16","0.43","0.22","0.22"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[7,41,23,11,4],"percentage":["1.51","8.86","4.97","2.38","0.86"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[46,85,41,29,22],"percentage":["9.94","18.36","8.86","6.26","4.75"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[42,50,19,12,7],"percentage":["9.07","10.8","4.1","2.59","1.51"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Wrapp D. et al. Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies // Cell. 2020. Vol. 181. No. 5. p. 1004-1015.e15.

GOST all authors (up to 50) Copy

Wrapp D., De Vlieger D., Corbett K. S., Torres G. M., Wang N., Van Breedam W., Roose K., Van Schie L., Hoffmann M., Pöhlmann S., Graham B., Callewaert N., Schepens B., Saelens X., McLellan J. S. Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies // Cell. 2020. Vol. 181. No. 5. p. 1004-1015.e15.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.cell.2020.04.031

UR - https://doi.org/10.1016/j.cell.2020.04.031

TI - Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

T2 - Cell

AU - Wrapp, Daniel

AU - De Vlieger, Dorien

AU - Corbett, Kizzmekia S.

AU - Torres, Gretel M

AU - Wang, Nianshuang

AU - Van Breedam, Wander

AU - Roose, K.

AU - Van Schie, Loes

AU - Hoffmann, Markus

AU - Pöhlmann, Stefan

AU - Graham, B.

AU - Callewaert, Nico

AU - Schepens, B.

AU - Saelens, Xavier

AU - McLellan, Jason S.

PY - 2020

DA - 2020/05/05 00:00:00

PB - Elsevier

SP - 1004-1015.e15

IS - 5

VL - 181

PMID - 32375025

SN - 0092-8674

SN - 1097-4172

ER -

BibTex |

Cite this

BibTex Copy

@article{2020_Wrapp,

author = {Daniel Wrapp and Dorien De Vlieger and Kizzmekia S. Corbett and Gretel M Torres and Nianshuang Wang and Wander Van Breedam and K. Roose and Loes Van Schie and Markus Hoffmann and Stefan Pöhlmann and B. Graham and Nico Callewaert and B. Schepens and Xavier Saelens and Jason S. McLellan},

title = {Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies},

journal = {Cell},

year = {2020},

volume = {181},

publisher = {Elsevier},

month = {may},

url = {https://doi.org/10.1016/j.cell.2020.04.031},

number = {5},

pages = {1004--1015.e15},

doi = {10.1016/j.cell.2020.04.031}

}

MLA

Cite this

MLA Copy

Wrapp, Daniel, et al. “Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.” Cell, vol. 181, no. 5, May. 2020, pp. 1004-1015.e15. https://doi.org/10.1016/j.cell.2020.04.031.

Found error?

Publisher

Elsevier

Journal

Cell

Quartile SCImago

Quartile WOS

Impact factor

64.5

ISSN

00928674 (Print)
10974172 (Electronic)