Cell, volume 183, issue 4, pages 1024-1042.e21
Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology
Luca Piccoli
,
Young W. Park
,
M. Tortorici
,
Nadine Czudnochowski
,
Alexandra C Walls
,
Martina Beltramello
,
Chiara Silacci-Fregni
,
Dora Pinto
,
L R Rosen
,
John E Bowen
,
Oliver J Acton
,
S. Jaconi
,
Barbara Guarino
,
Andrea Minola
,
Fabrizia Zatta
,
Nicole Sprugasci
,
Jessica Marcandalli
,
Alessia Peter
,
Anna De Marco
,
Jay Nix
,
Federico Mele
,
Sandra Jovic
,
Blanca Rodríguez
,
Sneha V Gupta
,
Jin Feng
,
Govanni Piumatti
,
Giorgia Lo Presti
,
Maira Biggiogero
,
Maciej Tarkowski
,
Matteo S Pizzuto
,
Elisabetta Cameroni
,
Colin Havenar Daughton
,
Megan Smithey
,
David Hong
,
Valentino Lepori
,
Emiliano Albanese
,
A Ceschi
,
E Bernasconi
,
Luigia Elzi
,
P Ferrari
,
Agostino Riva
,
Gyorgy Snell
,
FEDERICA SALLUSTO
,
Katja Fink
,
Herbert W. Virgin
,
Antonio Lanzavecchia
,
Davide Corti
,
David Veesler
Publication type: Journal Article
Publication date: 2020-11-01
PubMed ID:
32991844
General Biochemistry, Genetics and Molecular Biology
Abstract
Summary
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2 infection is crucial for understanding immune protection and identifying targets for vaccine design. In a cohort of 647 SARS-CoV-2-infected subjects, we found that both the magnitude of Ab responses to SARS-CoV-2 spike (S) and nucleoprotein and nAb titers correlate with clinical scores. The receptor-binding domain (RBD) is immunodominant and the target of 90% of the neutralizing activity present in SARS-CoV-2 immune sera. Whereas overall RBD-specific serum IgG titers waned with a half-life of 49 days, nAb titers and avidity increased over time for some individuals, consistent with affinity maturation. We structurally defined an RBD antigenic map and serologically quantified serum Abs specific for distinct RBD epitopes leading to the identification of two major receptor-binding motif antigenic sites. Our results explain the immunodominance of the receptor-binding motif and will guide the design of COVID-19 vaccines and therapeutics.Top-30
Citations by journals
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Frontiers in Immunology
58 publications, 4.87%
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Vaccines
37 publications, 3.11%
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Nature Communications
29 publications, 2.44%
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Cell Reports
28 publications, 2.35%
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Viruses
27 publications, 2.27%
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Science
23 publications, 1.93%
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Nature
20 publications, 1.68%
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Scientific Reports
19 publications, 1.6%
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Cell
18 publications, 1.51%
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iScience
18 publications, 1.51%
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npj Vaccines
15 publications, 1.26%
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Cell Host and Microbe
13 publications, 1.09%
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Microbiology spectrum
13 publications, 1.09%
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PLoS ONE
12 publications, 1.01%
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International Journal of Molecular Sciences
12 publications, 1.01%
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Immunity
10 publications, 0.84%
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PLoS Pathogens
10 publications, 0.84%
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Science Translational Medicine
9 publications, 0.76%
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Frontiers in Microbiology
8 publications, 0.67%
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Cell Reports Medicine
8 publications, 0.67%
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Journal of Virology
8 publications, 0.67%
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Proceedings of the National Academy of Sciences of the United States of America
8 publications, 0.67%
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Microorganisms
7 publications, 0.59%
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EBioMedicine
7 publications, 0.59%
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Emerging Microbes and Infections
7 publications, 0.59%
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mAbs
7 publications, 0.59%
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Communications Biology
6 publications, 0.5%
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Molecular Therapy
6 publications, 0.5%
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Vaccine
6 publications, 0.5%
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Citations by publishers
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Cold Spring Harbor Laboratory
280 publications, 23.53%
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Elsevier
237 publications, 19.92%
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Springer Nature
169 publications, 14.2%
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Multidisciplinary Digital Publishing Institute (MDPI)
116 publications, 9.75%
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Frontiers Media S.A.
80 publications, 6.72%
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Wiley
49 publications, 4.12%
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American Association for the Advancement of Science (AAAS)
46 publications, 3.87%
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American Society for Microbiology
28 publications, 2.35%
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Taylor & Francis
25 publications, 2.1%
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Public Library of Science (PLoS)
25 publications, 2.1%
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American Chemical Society (ACS)
21 publications, 1.76%
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Oxford University Press
15 publications, 1.26%
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Proceedings of the National Academy of Sciences (PNAS)
8 publications, 0.67%
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Royal Society of Chemistry (RSC)
7 publications, 0.59%
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American Society for Clinical Investigation
6 publications, 0.5%
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KeAi Communications Co.
4 publications, 0.34%
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The American Association of Immunologists
3 publications, 0.25%
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Wolters Kluwer Health
3 publications, 0.25%
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Pleiades Publishing
3 publications, 0.25%
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eLife Sciences Publications
3 publications, 0.25%
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Dove Medical Press
2 publications, 0.17%
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Future Medicine
2 publications, 0.17%
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Huazhong University of Science and Technology
2 publications, 0.17%
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Annual Reviews
2 publications, 0.17%
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American Society for Biochemistry and Molecular Biology
2 publications, 0.17%
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EMBO press
2 publications, 0.17%
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American Society of Nephrology
2 publications, 0.17%
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Rockefeller University Press
2 publications, 0.17%
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American Society for Pharmacology and Experimental Therapeutics
1 publication, 0.08%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Piccoli L. et al. Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology // Cell. 2020. Vol. 183. No. 4. p. 1024-1042.e21.
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Piccoli L., Park Y. W., Tortorici M., Czudnochowski N., Walls A. C., Beltramello M., Silacci-Fregni C., Pinto D., Rosen L. R., Bowen J. E., Acton O. J., Jaconi S., Guarino B., Minola A., Zatta F., Sprugasci N., Marcandalli J., Peter A., De Marco A., Nix J., Mele F., Jovic S., Rodríguez B., Gupta S. V., Feng J., Piumatti G., Lo Presti G., Franzetti-Pellanda A., Biggiogero M., Tarkowski M., Pizzuto M. S., Cameroni E., Havenar Daughton C., Smithey M., Hong D., Lepori V., Albanese E., Ceschi A., Bernasconi E., Elzi L., Ferrari P., Garzoni C., Riva A., Snell G., SALLUSTO F., Fink K., Virgin H. W., Lanzavecchia A., Corti D., Veesler D. Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology // Cell. 2020. Vol. 183. No. 4. p. 1024-1042.e21.
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TY - JOUR
DO - 10.1016/j.cell.2020.09.037
UR - https://doi.org/10.1016/j.cell.2020.09.037
TI - Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology
T2 - Cell
AU - Piccoli, Luca
AU - Park, Young W.
AU - Tortorici, M.
AU - Czudnochowski, Nadine
AU - Walls, Alexandra C
AU - Beltramello, Martina
AU - Silacci-Fregni, Chiara
AU - Pinto, Dora
AU - Rosen, L R
AU - Bowen, John E
AU - Acton, Oliver J
AU - Jaconi, S.
AU - Guarino, Barbara
AU - Minola, Andrea
AU - Zatta, Fabrizia
AU - Sprugasci, Nicole
AU - Marcandalli, Jessica
AU - Peter, Alessia
AU - De Marco, Anna
AU - Nix, Jay
AU - Mele, Federico
AU - Jovic, Sandra
AU - Rodríguez, Blanca
AU - Gupta, Sneha V
AU - Feng, Jin
AU - Piumatti, Govanni
AU - Lo Presti, Giorgia
AU - Franzetti-Pellanda, Alessandra
AU - Biggiogero, Maira
AU - Tarkowski, Maciej
AU - Pizzuto, Matteo S
AU - Cameroni, Elisabetta
AU - Havenar Daughton, Colin
AU - Smithey, Megan
AU - Hong, David
AU - Lepori, Valentino
AU - Albanese, Emiliano
AU - Ceschi, A
AU - Bernasconi, E
AU - Elzi, Luigia
AU - Ferrari, P
AU - Garzoni, C
AU - Riva, Agostino
AU - Snell, Gyorgy
AU - SALLUSTO, FEDERICA
AU - Fink, Katja
AU - Virgin, Herbert W.
AU - Lanzavecchia, Antonio
AU - Corti, Davide
AU - Veesler, David
PY - 2020
DA - 2020/11/01 00:00:00
PB - Elsevier
SP - 1024-1042.e21
IS - 4
VL - 183
PMID - 32991844
SN - 0092-8674
SN - 1097-4172
ER -
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@article{2020_Piccoli,
author = {Luca Piccoli and Young W. Park and M. Tortorici and Nadine Czudnochowski and Alexandra C Walls and Martina Beltramello and Chiara Silacci-Fregni and Dora Pinto and L R Rosen and John E Bowen and Oliver J Acton and S. Jaconi and Barbara Guarino and Andrea Minola and Fabrizia Zatta and Nicole Sprugasci and Jessica Marcandalli and Alessia Peter and Anna De Marco and Jay Nix and Federico Mele and Sandra Jovic and Blanca Rodríguez and Sneha V Gupta and Jin Feng and Govanni Piumatti and Giorgia Lo Presti and Alessandra Franzetti-Pellanda and Maira Biggiogero and Maciej Tarkowski and Matteo S Pizzuto and Elisabetta Cameroni and Colin Havenar Daughton and Megan Smithey and David Hong and Valentino Lepori and Emiliano Albanese and A Ceschi and E Bernasconi and Luigia Elzi and P Ferrari and C Garzoni and Agostino Riva and Gyorgy Snell and FEDERICA SALLUSTO and Katja Fink and Herbert W. Virgin and Antonio Lanzavecchia and Davide Corti and David Veesler},
title = {Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology},
journal = {Cell},
year = {2020},
volume = {183},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.cell.2020.09.037},
number = {4},
pages = {1024--1042.e21},
doi = {10.1016/j.cell.2020.09.037}
}
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Piccoli, Luca, et al. “Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.” Cell, vol. 183, no. 4, Nov. 2020, pp. 1024-1042.e21. https://doi.org/10.1016/j.cell.2020.09.037.