Multiple Sclerosis and Related Disorders, volume 55, pages 103157
T-cell responses to SARS-CoV-2 in multiple sclerosis patients treated with ocrelizumab healed from COVID-19 with absent or low anti-spike antibody titers
Marco Iannetta
1
,
Doriana Landi
2
,
Gaia Cola
2
,
Vincenzo Malagnino
1
,
Elisabetta Teti
1
,
Daniela Fraboni
3
,
Sandro Grelli
4
,
Luigi Coppola
1
,
Laura Campogiani
1
,
M. Andreoni
1
,
G. A. Marfia
,
Publication type: Journal Article
Publication date: 2021-10-01
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 4
ISSN: 22110348, 22110356
General Medicine
Neurology
Neurology (clinical)
Abstract
Disease modifying therapies for multiple sclerosis (MS) can impair the specific immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Specifically, it is recognized that ocrelizumab reduces or abrogates anti-SARS-CoV-2 antibody production after natural infection or vaccination, while very little is known about T-cell responses.We developed an interferon (IFN)-γ release assay (IGRA) to detect T-cell responses specific to SARS-CoV-2 after overnight stimulation of whole blood with peptide libraries covering the immunodominant sequence domains of the Spike glycoprotein (S) and the Nucleocapsid phosphoprotein (N).Five patients with MS receiving ocrelizumab treatment for at least 1 year and recovered from SARS-CoV-2 infection were enrolled in the study. Despite the absence or the very low concentration of anti-S antibodies, a T-cell response was detectable in all the five MS patients. These results are in accordance with the marked reduction of peripheral B-lymphocyte absolute counts induced by ocrelizumab, that, conversely, did not affect peripheral blood T-lymphocyte subset absolute and relative counts and CD4/CD8 ratio.The detection of specific T-cell responses to SARS-CoV-2 in patients receiving B-cell depleting therapies represents a useful tool to improve the diagnostic approach in SARS-CoV-2 infection and to accurately assess the immunological response after natural infection or vaccination.
Top-30
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1 publication, 3.23%
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Citations by publishers
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Springer Nature
6 publications, 19.35%
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3 publications, 9.68%
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2 publications, 6.45%
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1 publication, 3.23%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 3.23%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Iannetta M. et al. T-cell responses to SARS-CoV-2 in multiple sclerosis patients treated with ocrelizumab healed from COVID-19 with absent or low anti-spike antibody titers // Multiple Sclerosis and Related Disorders. 2021. Vol. 55. p. 103157.
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Iannetta M., Landi D., Cola G., Malagnino V., Teti E., Fraboni D., Buccisano F., Grelli S., Coppola L., Campogiani L., Andreoni M., Marfia G. A., Sarmati L. T-cell responses to SARS-CoV-2 in multiple sclerosis patients treated with ocrelizumab healed from COVID-19 with absent or low anti-spike antibody titers // Multiple Sclerosis and Related Disorders. 2021. Vol. 55. p. 103157.
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TY - JOUR
DO - 10.1016/j.msard.2021.103157
UR - https://doi.org/10.1016/j.msard.2021.103157
TI - T-cell responses to SARS-CoV-2 in multiple sclerosis patients treated with ocrelizumab healed from COVID-19 with absent or low anti-spike antibody titers
T2 - Multiple Sclerosis and Related Disorders
AU - Iannetta, Marco
AU - Landi, Doriana
AU - Cola, Gaia
AU - Malagnino, Vincenzo
AU - Teti, Elisabetta
AU - Fraboni, Daniela
AU - Buccisano, Francesco
AU - Grelli, Sandro
AU - Coppola, Luigi
AU - Campogiani, Laura
AU - Andreoni, M.
AU - Marfia, G. A.
AU - Sarmati, L.
PY - 2021
DA - 2021/10/01 00:00:00
PB - Elsevier
SP - 103157
VL - 55
SN - 2211-0348
SN - 2211-0356
ER -
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@article{2021_Iannetta,
author = {Marco Iannetta and Doriana Landi and Gaia Cola and Vincenzo Malagnino and Elisabetta Teti and Daniela Fraboni and Francesco Buccisano and Sandro Grelli and Luigi Coppola and Laura Campogiani and M. Andreoni and G. A. Marfia and L. Sarmati},
title = {T-cell responses to SARS-CoV-2 in multiple sclerosis patients treated with ocrelizumab healed from COVID-19 with absent or low anti-spike antibody titers},
journal = {Multiple Sclerosis and Related Disorders},
year = {2021},
volume = {55},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.msard.2021.103157},
pages = {103157},
doi = {10.1016/j.msard.2021.103157}
}