Nano Today, volume 42, pages 101350
Anti-SARS-CoV-1 and −2 nanobody engineering towards avidity-inspired therapeutics
3
Department of Chemical Engineering, University of Tennessee, Chattanooga 615 McCallie Ave, Chattanooga, TN 37403, United States
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Publication type: Journal Article
Publication date: 2022-02-01
Pharmaceutical Science
Biotechnology
General Materials Science
Bioengineering
Biomedical Engineering
Abstract
In the past two decades, the emergence of coronavirus diseases has been dire distress on both continental and global fronts and has resulted in the search for potent treatment strategies. One crucial challenge in this search is the recurrent mutations in the causative virus spike protein, which lead to viral escape issues. Among the current promising therapeutic discoveries is the use of nanobodies and nanobody-like molecules. While these nanobodies have demonstrated high-affinity interaction with the virus, the unpredictable spike mutations have warranted the need for avidity-inspired therapeutics of potent inhibitors such as nanobodies. This article discusses novel approaches for the design of anti-SARS-CoV-1 and -2 nanobodies to facilitate advanced innovations in treatment technologies. It further discusses molecular interactions and suggests multivalent protein nanotechnology and chemistry approaches to translate mere molecular affinity into avidity.
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Citations by publishers
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3 publications, 20%
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Wiley
3 publications, 20%
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3 publications, 20%
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Springer Nature
2 publications, 13.33%
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1 publication, 6.67%
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1 publication, 6.67%
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1 publication, 6.67%
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- We do not take into account publications without a DOI.
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- Statistics recalculated weekly.
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Obeng E. M., Dzuvor C. K. O., Zeng X. Anti-SARS-CoV-1 and −2 nanobody engineering towards avidity-inspired therapeutics // Nano Today. 2022. Vol. 42. p. 101350.
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Obeng E. M., Dzuvor C. K. O., Zeng X. Anti-SARS-CoV-1 and −2 nanobody engineering towards avidity-inspired therapeutics // Nano Today. 2022. Vol. 42. p. 101350.
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TY - JOUR
DO - 10.1016/j.nantod.2021.101350
UR - https://doi.org/10.1016/j.nantod.2021.101350
TI - Anti-SARS-CoV-1 and −2 nanobody engineering towards avidity-inspired therapeutics
T2 - Nano Today
AU - Obeng, Eugene Marfo
AU - Dzuvor, Christian K O
AU - Zeng, Xianhai
PY - 2022
DA - 2022/02/01 00:00:00
PB - Elsevier
SP - 101350
VL - 42
SN - 1748-0132
ER -
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@article{2022_Obeng,
author = {Eugene Marfo Obeng and Christian K O Dzuvor and Xianhai Zeng},
title = {Anti-SARS-CoV-1 and −2 nanobody engineering towards avidity-inspired therapeutics},
journal = {Nano Today},
year = {2022},
volume = {42},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.nantod.2021.101350},
pages = {101350},
doi = {10.1016/j.nantod.2021.101350}
}